Monthly Archives: June 2012

RNA-Seq – A Status Update

Hybridization- and tag-based technologies have elucidated the involvement of multiple genes and pathways in pathological conditions, providing insights into the expression of thousand of coding and noncoding RNAs, such as microRNAs. However, the introduction of Next-Generation Sequencing, particularly of RNA-Seq, ...

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RNA-Seq of Cone Snail Venom

The fish-hunting cone snail, Conus geographus, is the deadliest snail on earth. In the absence of medical intervention, 70% of human stinging cases are fatal. Although, its venom is known to consist of a cocktail of small peptides targeting different ...

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Dissect – a novel transcriptome-to-genome alignment tool

Dissect (DIScovery of Structural Alteration Event Containing Transcripts), a novel transcriptome-to-genome alignment tool, can identify and characterize transcriptomic events such as duplications, inversions, rearrangements and fusions. Dissect is suitable for whole transcriptome structural variation discovery problems involving sufficiently long reads ...

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Xenome – A tool for classifying reads from xenograft samples

Xenome performs fast, accurate and specific classification of xenograft-derived sequence read data. It has been evaluated on RNA-Seq data from human, mouse and human-in-mouse xenograft datasets. Availability: Xenome is available for non-commercial use from http://www.genomics.csse.unimelb.edu.au/product-xenome.php Conway T, Wazny J, Bromage ...

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Leveraging the Cancer Transcriptome for New Drug Targets

from Genetic Engineering News Instead of one gene or protein, the new paradigm in cancer research focuses on the analysis of entire sets of genes and proteins to identify drug targets. Multiple experimental and data analysis methodologies are being used ...

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Beta Testers Wanted – New RNA-Seq Data Analysis Software

The Ingenuity iReport team is currently developing features for the analysis and interpretation of human RNA-Seq isoform-specific data. They are adding functionality to support the visualization and interpretation of isoform-specific expression data and need your help making sure these new ...

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The Breast Cancer Landscape

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. A team led by researchers ...

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