AAEP Foundation to Fund RNA-Seq Research on Lameness in Horses

rna-seq

Support-limb laminitis was the type of laminitis 2006 Kentucky Derby winner Barbaro (seen here at the University of Pennsylvania’s New Bolton Center) succumbed to while healing from a severe fracture in a hind limb.

The American Association of Equine Practitioners (AAEP) Foundation has announced financial support for two research projects investigating support-limb laminitis, in which lameness in one limb results in laminitis in the opposite limb. Subsequent separation of the coffin bone from the hoof wall can cause pain and eventually displacement, either coffin bone rotation or sinking, in the foot.

Members of the AAEP have identified laminitis as the most important equine disease requiring research. Support-limb laminitis was the type of laminitis 2006 Kentucky Derby winner Barbaro succumbed to while healing from a severe fracture in a hind limb.

This study, led by Samantha Brooks, PhD, at the University of Florida, seeks to understand the response of the cells in the support structures within the hoof. By utilizing RNA sequencing, genes that respond to the abnormal support in the foot will be identified and compared to normal feet. Understanding the gene upregulation will help identify the process within the hoof that leads to support failure. The research will use real-time PCR to identify the production of inflammatory mediators and enzymes involved with the pathology.

A second study, Hana Galantino-Homer, VMD, PhD, Dipl. ACT, at the University of Pennsylvania will investigate the alterations that occur in the protein structure that supports the bone to the hoof connection.

“The generosity of many enabled us to fund these projects that will advance the knowledge and help unravel the mysteries surrounding this insidious disease,” said Jeff Berk, VMD, chairman of the AAEP Foundation Advisory Council.

Source – The Horse

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