Bacterial Transcriptomics

RNA-Seq or high-throughput sequencing of transcriptomes is sweeping through clinical microbiology, transforming the discipline in its wake. Early studies have uncovered a wealth of novel coding sequences and non-coding RNA, and are revealing a transcriptional landscape that increasingly mirrors that of eukaryotes.

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van Vliet AH. (2010) Next generation sequencing of microbial transcriptomes: challenges and opportunities. FEMS Microbiol Lett 302(1), 1-7. [abstract]

Pallen MJ, Loman NJ, Penn CW. (2010) High-throughput sequencing and clinical microbiology: progress, opportunities and challenges. Curr Opin Microbiol 13(5), 625-31. [abstract]

Skvortsov TA, Azhikina TL. (2010) Transcriptome analysis of bacterial pathogens in vivo: problems and solutions. Bioorg Khim 36(5), 596-606. [abstract]

Passalacqua KD, Varadarajan A, Ondov BD, Okou DT, Zwick ME, Bergman NH. (2009) Structure and complexity of a bacterial transcriptome. J Bacteriol 191(10), 3203-11. [abstract]