BreakFusion is a software package, that combines the strength of reference alignment followed by read-pair analysis and de novo assembly to achieve a good balance in sensitivity, specificity, and computational efficiency for identification of gene fusions from next-generation whole transcriptome sequencing (RNA-Seq) data.
- Chen K et. Al. (2012) BreakFusion: Targeted Assembly-based Identification of Gene Fusions in Whole Transcriptome Paired-end Sequencing Data. Bioinformatics [Epub ahead of print]. [abstract]