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Mapping Splicing Quantitative Trait Loci in RNA-Seq

Mapping Splicing Quantitative Trait Loci in RNA-Seq

One of the major mechanisms of generating mRNA diversity is alternative splicing, a regulated process that allows for the flexibility of producing functionally different proteins from the same genomic sequences. This process is often altered in cancer cells to produce ...

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Impact of gene annotation on RNA-Seq data analysis

Impact of gene annotation on RNA-Seq data analysis

RNA-Seq has become increasingly popular in transcriptome profiling. One aspect of transcriptome research is to quantify the expression levels of genomic elements, such as genes, their transcripts and exons. Acquiring a transcriptome expression profile requires genomic elements to be defined ...

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Removing technical noise from single cell RNA-Seq data

Removing technical noise from single cell RNA-Seq data

Single-cell RNA-seq is a promising technology with broad applications and discerning biological noise from technical noise is critical for correctly interpreting the data (Jaitin, et al., 2014). Recently, statistical methods are developed to model the technical noise from spike-in ERCC ...

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