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miTALOS v2 – Analyzing Tissue Specific microRNA Function

miTALOS v2 – Analyzing Tissue Specific microRNA Function

MicroRNAs are involved in almost all biological processes and have emerged as regulators of signaling pathways. Researchers from the German Research Center for Environmental Health show that miRNA target genes and pathway genes are not uniformly expressed across human tissues. To ...

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BBBomics – Human Blood Brain Barrier Transcriptomics Hub

BBBomics – Human Blood Brain Barrier Transcriptomics Hub

Blood-brain barrier (BBB) is a monolayer of endothelial cells that line brain capillaries. The BBB protects brain by blocking the entry of harmful substances from blood and shielding the brain from peripheral fluctuations in hormones, fatty acids, and electrolytes. In ...

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A comprehensive overview of lncRNA annotation resources

A comprehensive overview of lncRNA annotation resources

Long noncoding RNAs (lncRNAs) are emerging as a class of important regulators participating in various biological functions and disease processes. With the widespread application of next-generation sequencing technologies, large numbers of lncRNAs have been identified, producing plenty of lncRNA annotation ...

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DsTRD – Danshen Transcriptional Resource Database

DsTRD – Danshen Transcriptional Resource Database

Salvia miltiorrhiza has been comprehensively studied as a medicinal model plant. However, research progress on this species is significantly hindered by its unavailable genome sequences and limited number of expressed sequence tags in the National Center for Biotechnology Information database. ...

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Bioinformatics Resources for MicroRNA Discovery

Bioinformatics Resources for MicroRNA Discovery

Biomarker identification is often associated with the diagnosis and evaluation of various diseases. Recently, the role of microRNA (miRNA) has been implicated in the development of diseases, particularly cancer. With the advent of next-generation sequencing, the amount of data on ...

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The Mammalian Transcriptomic Database

The Mammalian Transcriptomic Database

A systematic transcriptome survey is essential for the characterization and comprehension of the molecular basis underlying phenotypic variations. Recently developed RNA-seq methodology has facilitated efficient data acquisition and information mining of transcriptomes in multiple tissues/cell lines. Current mammalian transcriptomic databases ...

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RNA sequencing of the nephron transcriptome: a technical note

RNA sequencing of the nephron transcriptome: a technical note

To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool. RNA sequencing (RNA-seq) has revolutionized transcriptomic research, enabling researchers to define transcription activity and ...

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WheatExp – an RNA-seq expression database for polyploid wheat

WheatExp – an RNA-seq expression database for polyploid wheat

For functional genomics studies, it is important to understand the dynamic expression profiles of transcribed genes in different tissues, stages of development and in response to environmental stimuli. The proliferation in the use of next-generation sequencing technologies by the plant ...

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