Other Tools

An evaluation of high-throughput isomiR identification tools

MicroRNAs carry out post-transcriptional gene regulation in animals by binding to the 3′ untranslated regions of mRNAs, causing their degradation or translational repression. MicroRNAs influence many biological functions, and dysregulation can therefore disrupt development or even cause death. High-throughput sequencing ...

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Gene expression should be analyzed on the isoform level

rna-seq

Alternative usage of transcript isoforms from the same gene has been hypothesized as an important feature in cancers. However, differential usage of gene transcripts between conditions – isoform switching – has not been comprehensively characterized in and across cancer types. ...

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