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Comparing Data Across RNA-Seq Studies

Comparing Data Across RNA-Seq Studies

High-throughput sequencing is now regularly used for studies of the transcriptome (RNA-seq), particularly for comparisons among experimental conditions. For the time being, a limited number of biological replicates are typically considered in such experiments, leading to low detection power for ...

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Improved Transcript Isoform Discovery using ORF Graphs

Improved Transcript Isoform Discovery using ORF Graphs

High-throughput sequencing of RNA in vivo facilitates many applications, not the least of which is the cataloging of variant splice isoforms of protein-coding messenger RNAs. While many solutions have been proposed for reconstructing putative isoforms from deep sequencing data, these ...

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TSSAR: TSS annotation regime for dRNA-seq data

TSSAR: TSS annotation regime for dRNA-seq data

Differential RNA sequencing (dRNA-seq) is a high-throughput screening technique designed to examine the architecture of bacterial operons in general and the precise position of transcription start sites (TSS) in particular. Hitherto, dRNA-seq data were analyzed by visualizing the sequencing reads ...

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FANTOM5 releases atlas of human gene expression

FANTOM5 releases atlas of human gene expression

FANTOM, a large international consortium led by RIKEN releases today the first comprehensive map of gene activity across the human body, and provides the first holistic view of the complex networks that regulate gene expression across the wide variety of ...

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INsPeCT: INtegrative Platform for Cancer Transcriptomics

INsPeCT: INtegrative Platform for Cancer Transcriptomics

The emergence of transcriptomics, fuelled by high-throughput sequencing technologies, has changed the nature of cancer research and resulted in a massive accumulation of data. Computational analysis, integration, and data visualization are now major bottlenecks in cancer biology and translational research. ...

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