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An Integrated Approach for RNA-seq Data Normalization

An Integrated Approach for RNA-seq Data Normalization

DNA copy number alteration is common in many cancers. Studies have shown that insertion or deletion of DNA sequences can directly alter gene expression, and significant correlation exists between DNA copy number and gene expression. Data normalization is a critical ...

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The Ensembl gene annotation system

The Ensembl gene annotation system

The Ensembl gene annotation system has been used to annotate over 70 different vertebrate species across a wide range of genome projects. Furthermore, it generates the automatic alignment-based annotation for the human and mouse GENCODE gene sets. The system is ...

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Pseudotime Estimation – Deconfounding Single Cell Time Series

Pseudotime Estimation – Deconfounding Single Cell Time Series

Repeated cross-sectional time series single cell data confound several sources of variation, with contributions from measurement noise, stochastic cell-to-cell variation and cell progression at different rates. Time series from single cell assays are particularly susceptible to confounding as the measurements ...

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