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Using REDItools to Detect RNA Editing Events in NGS Datasets

Using REDItools to Detect RNA Editing Events in NGS Datasets

RNA editing is a post-transcriptional/co-transcriptional molecular phenomenon whereby a genetic message is modified from the corresponding DNA template by means of substitutions, insertions, and/or deletions. It occurs in a variety of organisms and different cellular locations through evolutionally and biochemically ...

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AltAnlayze Bulk and Single Cell RNA-Seq Tutorial

AltAnlayze Bulk and Single Cell RNA-Seq Tutorial

  Nathan Salomonis – Video illustrating how easy it is to analyze transcriptome datasets in AltAnalyze. Here we analyze a published single-cell gene expression dataset, supplied as a supplemental table, according to known biological groups and using a de novo ...

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Mapping Splicing Quantitative Trait Loci in RNA-Seq

Mapping Splicing Quantitative Trait Loci in RNA-Seq

One of the major mechanisms of generating mRNA diversity is alternative splicing, a regulated process that allows for the flexibility of producing functionally different proteins from the same genomic sequences. This process is often altered in cancer cells to produce ...

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Impact of gene annotation on RNA-Seq data analysis

Impact of gene annotation on RNA-Seq data analysis

RNA-Seq has become increasingly popular in transcriptome profiling. One aspect of transcriptome research is to quantify the expression levels of genomic elements, such as genes, their transcripts and exons. Acquiring a transcriptome expression profile requires genomic elements to be defined ...

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