Splicing and Junction Mapping

Feed Subscription

Kleat – cleavage site analysis of transcriptomes

Kleat – cleavage site analysis of transcriptomes

In eukaryotic cells, alternative cleavage of 3′ untranslated regions (UTRs) can affect transcript stability, transport and translation. For polyadenylated (poly(A)) transcripts, cleavage sites can be characterized with short-read sequencing using specialized library construction methods. However, for large-scale cohort studies as ...

Read More »

SNPlice – identify cis-acting, splice-modulating variants from RNA-seq datasets

SNPlice – identify cis-acting, splice-modulating variants from RNA-seq datasets

The growing recognition of the importance of splicing in eukaryotes, together with rapidly accumulating RNA-sequencing data, demand robust high-throughput approaches, which efficiently analyze experimentally derived whole-transcriptome splice profiles. Researchers from The George Washington University have developed a computational approach, called ...

Read More »
Scroll To Top