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Enabling large-scale next-generation sequence assembly with Blacklight

Enabling large-scale next-generation sequence assembly with Blacklight

A variety of extremely challenging biological sequence analyses were conducted on the XSEDE large shared memory resource Blacklight, using current bioinformatics tools and encompassing a wide range of scientific applications. These include genomic sequence assembly, very large metagenomic sequence assembly, ...

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A comparison of De novo short read sequence assemblers

A comparison of De novo short read sequence assemblers

The sequencing, de novo assembly and annotation of transcriptome datasets generated with next generation sequencing (NGS) has enabled biologists to answer genomic questions in non-model species with unprecedented ease. Reliable and accurate de novo assembly and annotation of transcriptomes, however, ...

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FANSe2: A Robust Tool for Quantitative NGS Applications

FANSe2: A Robust Tool for Quantitative NGS Applications

Correct and bias-free interpretation of the deep sequencing data is inevitably dependent on the complete mapping of all mappable reads to the reference sequence, especially for quantitative RNA-seq applications. Seed-based algorithms are generally slow but robust, while Burrows-Wheeler Transform (BWT) ...

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