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Fine-mapping cellular QTLs with RASQUAL and ATAC-seq

Fine-mapping cellular QTLs with RASQUAL and ATAC-seq

When cellular traits are measured using high-throughput DNA sequencing, quantitative trait loci (QTLs) manifest as fragment count differences between individuals and allelic differences within individuals. Researchers from the Wellcome Trust Sanger Institute have developed RASQUAL (Robust Allele-Specific Quantitation and Quality Control), ...

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Mapping RNA-seq Reads with STAR

Mapping RNA-seq Reads with STAR

Mapping of large sets of high-throughput sequencing reads to a reference genome is one of the foundational steps in RNA-seq data analysis. The STAR software package performs this task with high levels of accuracy and speed. In addition to detecting ...

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RASER – Reads Aligner for SNPs and Editing sites of RNA

RASER – Reads Aligner for SNPs and Editing sites of RNA

Accurate identification of genetic variants such as single nucleotide polymorphisms (SNPs) or RNA editing sites from RNA-Seq reads is important, yet challenging, because it necessitates a very low false positive rate in read mapping. Although many read aligners are available, ...

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