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Auto req	18388BR
Job Posting Title	Scientist – Genome Analysis Unit
Career Category	Scientific
Employee Subgroup	Salaried FT
Country (State/Region)	United States – California United States – Washington
Location (City)	US – WA – Seattle US – CA – South San Francisco US – CA – Thousand Oaks
Amgen Job Description	The successful employee will be part of the computational biology group in the Genome Analysis Unit (GAU), applying advanced techniques in bioinformatics, statistical analysis, and programming to biological problems across a wide range of human disease areas at Amgen. In particular, the employee will work with large biological data sets including Next Generation Sequencing (NGS) data (RNA-Seq, Genome/Exome-Seq, etc.), microarray expression and copy number data, and high-throughput screening data. The GAU is a strategic innovation group within Discovery Research at Amgen. The group has members located in 3 geographic sites and consists of 40 staff members. The group operates semi-autonomously but also collaboratively across all Research to deliver novel drug targets, biomarkers, and innovative solutions to accelerate and enable the drug discovery efforts at Amgen. Read more

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• www rna-seqblog com featured-rna-seq-job-scientist-genome-analysis-unit-amgen

Bioinformatician
1370806
CLARiENT, a GE Healthcare company

At Clarient, we combine innovative diagnostic technologies with world-class pathology expertise to assess and characterize cancer. Our mission is to become the leader in cancer diagnostics by dedicating ourselves to collaborative relationships with the healthcare community to translate cancer discovery and research into better patient care. Our principal customers include pathologists, oncologists, hospitals and biopharmaceutical companies. Read more

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Please feel free to contact me at bhamory@theranos.com

Theranos is actively building a world-class team. Ideal candidates are currently employed or have been employed in similar types of positions and want to be part of a paradigm-shifting company doing innovative work. Candidates must be hard-working with an unfaltering determination to excel in an intense start-up environment and a desire to gain tremendous personal and career growth. Read more

The group “Systems Biology of the Cellular Microenvironment” at the Institute for Molecular Medicine and Cell Research (IMMZ), U, is offering

 

one Post-Doc position in Systems Biology and Data Analysis

for three years, starting as soon as possible. Salary will be according to E13 TV-L.
The position within the joint experimental and theoretical systems biology group, headed by Dr. Dr. Melanie Börries and Dr. Hauke Busch, will deal with bioinformatic analysis and modelling of time-resolved microarray and RNA-Seq data. In combination with proteome and high-throughput imaging data the goal is to develop multi-scale models for the simulation and control of microspore derived embryo formation in plants. The positions are part of the newly established BMBF research consortium Microsystems (“BioSystems analysis of microspores to improve industrial plant embryo production”). Read more

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Job Description

Xylo Technologies Inc. is an established Information Technology organization that serves Fortune and Mid-Tier corporations. Xylo has been ranked 750th by Inc. 5000 as one of the fastest growing private companies in America.

Xylo Technologies, Inc offers the best salary package with benefits for the right candidate. Xylo is an equal opportunity employer. Please apply if your skill set matches the requirements mentioned below.

Bioinformatics rna-seq proteomics Java developer
Location – Rochester MN
Duration – 1 year

Number of opening – 2 Read more

Job Number:	83192857
Company Name:	Infinity Pharmaceuticals, Inc.
Location:	Cambridge, MA US
Career Focus:	Management & Business

Computational Biology Summer Intern

Tracking Code
172861-106
Job Description

Infinity Pharmaceuticals is an innovative cancer drug discovery and development company seeking to leverage its strength in small molecule drug technologies to discover, develop, and deliver to patients first-in-class or best-in-class medicines for the treatment of cancer and related conditions. Read more

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Supervisors

Dr Qiongyi Zhao qiongyi.zhao@uq.edu.au

Dr Kostya Shakhbazov k.shakhbazov@uq.edu.au

A/Prof Naomi Wray naomi.wray@uq.edu.au

Project Description

Alternative splicing (AS) is a regulated process during gene expression that results in a single gene locus transcribing to multiple isoforms. It is well known that alternative splicing occurs as a normal phenomenon in eukaryotes, and alternative pre-mRNA splicing affects the majority of human genes and plays important roles in development and disease. However, the methodology for accurate identification of AS events based on high throughput sequencing data is not yet well developed. Current publically available tools/packages like “DEXSeq” and “cufflinks” only focus on differential usage of exons in known isoforms or just provide partial results for AS events. Thus, it is essential to develop new analytical methods or tools to accurately identify AS events and facilitate the RNA-Seq community to study AS events.

The PhD project will involve developing a user-friendly tool to identify AS events based on RNA-Seq data sets and analysing AS events in human transcriptome sequencing data. Analyses may focus on AS events in disease vs control (for example Motor Neurone Disease or Schizophrenia) or in male vs. female. Development of a user-friendly tool is essential and important for the RNA-Seq community.

The PhD student will be based within the QBI bioinformatics core that supports all sequencing projects undertaken on the in-house Illumina HiSeq. The student will be exposed to a range of ongoing projects and will learn skills in computational approaches/pipelines to integrate and analyze large-scale NGS data sets including genomics, expression, transcriptomics, epigenomics and proteomics data sets for scientific discovery and validation. A small sequencing project designed by the student could also be part of the project.

Read more at : http://www.complextraitgenomics.com/phd_positions/

 

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Position Title: SCIENTIST (Computational Biologist) Grade 26

Position ID: 1281130206

Description

Johnson & Johnson Pharmaceutical Research & Development L.L.C., a member of Johnson and Johnson’s family of companies, is recruiting for a Research Scientist for Molecular Profiling, located in Spring House, PA.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine. Read more

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Research Associate III Baylor Research Institute Dallas Bioinformatics\Computational Biology Weekday
Job Number:	81099147
Company Name:	Baylor Health Care System
Location:	Dallas, TX US
Career Focus:	Healthcare & Medical / Science & Biotech
Apply to Job
Read more

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Postdoctoral Researcher (Molecular Genetics) Primordial Dwarfism and Organism Growth

School of Molecular, Genetic and Population Health Sciences

£30,424 – £36,298

A postdoctoral researcher is sought for a three year post in Dr Andrew Jackson’s group to investigate the genetic basis of organism size.

For full advert details please visit: http://recruitment.mvm.ed.ac.uk/009884.pdf

The successful applicant will be involved in the identification of novel primordial dwarfism genes using NGS sequencing strategies. Exome (~150 patients) and RNAseq data is already available from our large cohort of patients with extreme growth reduction. Additionally, the postholder will investigate whether intermediate effect alleles in such genes are physiological determinants of body and brain size utilising available collaborator datasets and through their own resequencing studies. There will also be the opportunity to be involved in follow-up cellular and developmental functional studies. Read more

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Job Number:	79287699
Company Name:	Pfizer Inc.
Location:	Cambridge, MA US
Career Focus:	Information Technology / Science & Biotech

Senior / Principal Scientist / Data Analyst, Exploratory

All over the world, Pfizer colleagues are working together to positively impact health for everyone, everywhere. Each position at Pfizer touches and contributes to the success of our business and our world. That’s why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed to seeking out inspired new talent who share our core values and mission of making the world a healthier place. Read more

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Computational Biologist – Novartis Pharmaceuticals (United States)

…in cell or molecular biology .Expertise in genomic data analysis – particularly RNA – seq , polymorphism discovery, and other NGS methods .A demonstrated understanding

Lab Head, NGDx Analytical Lab, PhD – Novartis Pharmaceuticals (United States)

…ideal candidate will be experienced in using various types of NGS data (Exome, RNA – Seq , etc) for studying the cancer genome and associated signaling pathways.

SCIENTIST Job – Janssen Research & Development, LLC. (60 (United States)

…techniques for analyzing data generated using high throughput platforms ( such as RNA – seq , microarrays, genotyping) is required. Expertise in building and analyzing

Summer Internship at Millennium – Clinical Development – Randstad (United States)

…and copy number estimation (exome sequencing) and differential gene expression ( RNA – Seq ). *Run downstream bioinformatics analysis including gene ontology (GO)

Sr. Prgmr Analyst/Bioinformatics – Columbia University (United States)

…BLAST as well as understanding of algorithms behind them. Experience with the analysis of RNA – Seq data is a plus. Basic knowledge of genetics and molecular biology

Bioinformatics Specialist – Scripter – Randstad (United States)

…farm infrastructure –BS/MS/PhD in Bioinformatics or a related field –Experience with RNA – Seq read mapping and analysis –Experience with de novo transcriptome

Bioinformatics Specialist – Scripter – Randstad (United States)

…farm infrastructure –BS/MS/PhD in Bioinformatics or a related field –Experience with RNA – Seq read mapping and analysis –Experience with de novo transcriptome

Incoming search terms:

• Google Janssen Mm10

Intern Product Development

Job Location: Austin, TX
The successful candidate will support product development activities for gene expression analysis through next generation sequencing (NGS). The candidate will be required to plan, execute, and clearly document experiments in support of RNA-Seq technology development. Candidates should have a solid educational background in molecular biology or biochemistry as well as some laboratory experience working with nucleic acid isolation and purification. Experience with RT-PCR, siRNA, nucleic acid amplification, or next generation sequencing is a plus. Candidate should be detail-oriented, self-motivated, and display an eagerness to learn.

Throughout the course of the internship, the candidate will be trained in nucleic acid sample preparation and extraction techniques from different biological matrices, PCR, nucleic acid characterization, and library preparation for NGS, and . The candidate will also be required to provide written reports and give oral presentations summarizing experimental results to the research and development team. Read more

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• INTERNSHIP&AVAILABLE

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• SEQanswers – RNA Sequencing

  • HT Seq Count stranded options May 24, 2013
    I am very new to bioinformatics, so I would be really grateful for some help! I have been using *HTSeq Count v0.5.3* and I am bit confused about... […]
    qwrissie
  • Tophat 2.0.8b installation error May 24, 2013
    I install tophat-2.0.8b to rerun the mapping. but when i make it, the error appears like this. make[1]: Entering directory... […]
    canhu
  • reason for low mapping rate?? May 23, 2013
    we did RNASeq using HiSeq 2000 100PE. When the data were back, I mapping them to the reference sequence, but got very low mapping rate (30-40%). I... […]
    miaom
  • cross-species data - questions about normalization May 23, 2013
    Hi, I have some data form various samples (cell types) in different species. I want to compare and analyze gene expression variability across the... […]
    trelek2
  • CuffDiff strange output May 23, 2013
    Hi, I hope that someone can be so gentle to help me. I'm analizing some data from RNA-Seq with TopHat and Cufflinks and I focus my attention on... […]
    Pruexel
  • cannot away with cuffdiff,incredible May 23, 2013
    Hi,all I have 4(A,B,C,D) sample in 4 times(increasing time),I got diff result in 3 different cuffdiff 1.cuffdiff 3(A,B,C) individual... […]
    upper

• Biostar – RNA-Seq

  • Why am I getting so many unmapped reads in STAR, classified as "too short"?
    I am currently using STAR to map several Hi-SEQ mRNA runs. I'm having trouble getting a decent amount of reads to map, but I don't really understand why. I'm hoping you can shed some light :) In the final log, only about 50% (or less) of the reads map to the reference. I'm using a GTF in addition to the genome. The unmapped bin that most […]
  • What are the best practices for SNP identification in RNA seq transcriptome data
    I have 20 RICE RNA seq tranascriptome data hiseq 2000 platform paired end reads. I aligned fasta reads with BWA and remove PCR duplicates with PICARD. Later I call SNP with samtools using various parameters. I would like to clarify what parameters should I used while alinging to reference rice genome for looking SNP location 100 bp upstream and 250 bp downst […]
  • How do TopHat options -g , --supress-hits, and Bowtie options interplay?
    Hi, I am currently using TopHat2 to map RNA-seq runs. I think there have been some changes pertaining the -g option. Does anyone know how it works now? I used to think that setting -g would look for n alignments for a given read, report them [if top-scoring] and discard those reads that had more than g [top scoring] alignments. Now, the description sounds mo […]
  • What happened to -k in TopHat for multiple-mapping reads?
    Selecting -g n in tophat does not discard reads mapping more than n, but instead only reports n alignments for those out all all their TOP scoring alignments. I think there used to be an option -k that would allow one to discard reads that topped x alignments -- whatever happened to that? I only see -g in the tophat 2 manual, no reporting options like before […]
  • Does tophat use the library-type information for mapping, or just for the XS flag?
    When I specify library-type to TopHat, i.e., first-strand, second-strand, unstranded, TopHat appends a value + or - to the XS:A flag, which is useful for subsequent analyses, such as annotation. However, does this information actually influence the "mappability" of reads, or is this unaffected? My thinking is that the information would be considere […]
  • Purpose of Y-shaped adapters in Illumina Sequencing?
    Hi all, Y adapters different sequences to be annealed to the 5' and 3' ends of each molecule in a library. The arms of the Y are unique, and the middle part, connected to the DNA fragment, is complementary. What are the advantages of this? My take of this over having fully-complementary adapters (ADAPTER1 - - - - - ADAPTER1) is that: -Upon primer a […]