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RNA-seq gene profiling – a systematic empirical comparison

RNA-seq gene profiling – a systematic empirical comparison

RNA-seq gene profiling – a systematic empirical comparison Nuno A Fonseca, John A Marioni, Alvis Brazma Accurately quantifying gene expression levels is a key goal of experiments using RNA-sequencing to assay the transcriptome. This typically requires aligning the short reads ...

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CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

The global shortening of messenger RNAs through alternative polyadenylation (APA) that occurs during enhanced cellular proliferation represents an important, yet poorly understood mechanism of regulated gene expression. The 3′ untranslated region (UTR) truncation of growth-promoting mRNA transcripts that relieves intrinsic ...

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