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Diversity of human tRNA genes from the 1000-genomes project

Diversity of human tRNA genes from the 1000-genomes project

The sequence diversity of individual human genomes has been extensively analyzed for variations and phenotypic implications for mRNA, miRNA, and long non-coding RNA genes. TRNA (tRNA) also exhibits large sequence diversity in the human genome, but tRNA gene sequence variation ...

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Focus on RNA Secondary Structure

Focus on RNA Secondary Structure

In parallel to the genetic code for protein synthesis, a second layer of information is embedded in all RNA transcripts in the form of RNA structure. RNA structure influences practically every step in the gene expression program. However, the nature ...

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The MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing

The MicroRNA Expression Signature of Bladder Cancer by Deep Sequencing

Current genome-wide microRNA (miRNA) expression signature analysis using deep sequencing technologies can drive the discovery of novel cancer pathways regulated by oncogenic and/or tumor suppressive miRNAs. Researchers at Kagoshima University, Japan determined the genome-wide miRNA expression signature in bladder cancer ...

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A dynamic alternative splicing program regulates gene expression

A dynamic alternative splicing program regulates gene expression

Alternative pre-messenger RNA splicing remodels the human transcriptome in a spatiotemporal manner during normal development and differentiation. Here researchers from the University of California, Berkeley explored the landscape of transcript diversity in the erythroid lineage by RNA-seq analysis of five ...

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Transcriptome analysis of alternative splicing events

Transcriptome analysis of alternative splicing events

Splicing factor SRSF10 is known to function as a sequence-specific splicing activator. Here, researchers at the Chinese Academy of Sciences used RNA-seq coupled with bioinformatics analysis to identify the extensive splicing network regulated by SRSF10 in chicken cells. They found ...

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