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RNA-Seq methods for transcriptome analysis

RNA-Seq methods for transcriptome analysis

Deep sequencing has been revolutionizing biology and medicine in recent years, providing single base-level precision for our understanding of nucleic acid sequences in high throughput fashion. Sequencing of RNA, or RNA-Seq, is now a common method to analyze gene expression ...

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The snoRNAome

The snoRNAome

Small nucleolar RNAs (snoRNAs) are a class of non-coding RNAs that guide the post-transcriptional processing of other non-coding RNAs (mostly ribosomal RNAs), but have also been implicated in processes ranging from microRNA-dependent gene silencing to alternative splicing. In order to ...

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Application of single-cell RNA-seq in the design of an anticancer regimen

Application of single-cell RNA-seq in the design of an anticancer regimen

Intratumoral heterogeneity hampers the success of marker-based anticancer treatment because the targeted therapy may eliminate a specific subpopulation of tumor cells while leaving others unharmed. Accordingly, a rational strategy minimizing survival of the drug-resistant subpopulation is essential to achieve long-term ...

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Fighting veterinary drug abuse with RNA-Seq

Fighting veterinary drug abuse with RNA-Seq

Worldwide growth and performance-enhancing substances are used in cattle husbandry to increase productivity. In certain countries however e.g., in the EU, these practices are forbidden to prevent the consumers from potential health risks of substance residues in food. To maximize ...

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Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics

Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics

Mouse studies have been instrumental in forming our current understanding of early cell-lineage decisions; however, similar insights into the early human development are severely limited. Here, researchers from the Karolinska Institutet present a comprehensive transcriptional map of human embryo development, ...

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