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RNA-Seq reveals distinct features of exosomal small RNA

RNA-Seq reveals distinct features of exosomal small RNA

Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and transmitted between mammalian cells via extracellular vesicles (EVs), including endosome-derived exosomes. The small RNA composition in cells differs from exosomes, but underlying mechanisms have not been established. Researchers from the ...

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Considerations for RNA-Seq Analysis of Circadian Rhythms

Considerations for RNA-Seq Analysis of Circadian Rhythms

Circadian rhythms are daily endogenous oscillations of behavior, metabolism, and physiology. At a molecular level, these oscillations are generated by transcriptional-translational feedback loops composed of core clock genes. In turn, core clock genes drive the rhythmic accumulation of downstream outputs-termed ...

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Complex in vivo RNA-Seq of a Bacterial Pathogen

Complex in vivo RNA-Seq of a Bacterial Pathogen

Researchers at Umeå University recently found that Yersinia pseudotuberculosis can be used as a model of persistent bacterial infections. They performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at early and persistent stages of infection to determine ...

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scLVM – identification of hidden subpopulations of cells in RNA-Seq data

scLVM –  identification of hidden subpopulations of cells in RNA-Seq data

Highlights New method improves single-cell genomics analyses; Method clarifies the true differences and similarities between cells by modelling relatedness and removing confounding variables; Scientists can use known molecular pathways to better understand cancer cells, differentiation processes and the pathogenesis of ...

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