Technology

STAR – an ultrafast universal RNA-Seq aligner

Spliced Transcripts Alignment to a Reference (STAR) Accurate alignment of high-throughput RNA-Seq data is a challenging and yet unsolved problem because of the non-contiguous transcript structure, relatively short read lengths and constantly increasing throughput of the sequencing technologies. Currently available ...

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RNA-Seq Quantification – Presentation

  UZH/ETH – FGCZ – Functional Genomics Center Zurich www.fgcz.ch/ The Functional Genomics Center Zurich (FGCZ) is a joint state-of-the-art research and training facility of the ETH Zurich and the University of Zurich. With latest technologies and expert support in ...

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Sex-biased transcriptome evolution in Drosophila

Sex-biased genes are thought to drive phenotypic differences between males and females. The recent availability of high-throughput gene expression data for many related species has led to a burst of investigations into the genomic and evolutionary properties of sex-biased genes. ...

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A standard format for representing gene fusion data

There currently exists no community standardization approach to organize and represent genomic structural variation data with the essential attributes in an interchangeable manner. As transcriptome studies have been widely used for gene fusion discoveries, the current non-standard mode of data ...

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RNA-Seq Assembly – Are We There Yet?

Transcriptomic sequence resources represent invaluable assets for research, in particular for non-model species without a sequenced genome. To date, the Next Generation Sequencing technologies 454/Roche and Illumina have been used to generate transcriptome sequence databases by RNA-Seq for more than ...

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