Technology

An evaluation of high-throughput isomiR identification tools

MicroRNAs carry out post-transcriptional gene regulation in animals by binding to the 3′ untranslated regions of mRNAs, causing their degradation or translational repression. MicroRNAs influence many biological functions, and dysregulation can therefore disrupt development or even cause death. High-throughput sequencing ...

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Biomarker detection and categorization in ribonucleic acid sequencing meta-analysis using Bayesian hierarchical models

rna-seq

Meta-analysis combining multiple transcriptomic studies increases statistical power and accuracy in detecting differentially expressed genes. As the next-generation sequencing experiments become mature and affordable, increasing number of RNA-seq datasets are available in the public domain. The count-data based technology provides ...

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A different perspective, in contrast to traditional correlation analyses, its about capturing transcriptomic similarity

rna-seq

Comparative transcriptomics has gained increasing popularity in genomic research thanks to the development of high-throughput technologies including microarray and next-generation RNA sequencing that have generated numerous transcriptomic data. An important question is to understand the conservation and divergence of biological ...

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Having fun with single-cell RNA-seq

rna-seq

Computational Genomics Summer Institute 2017 Research Talk: “Having fun with single-cell RNA-seq: imputation and manifolds” Dana Pe’er, Sloan Kettering Institute Institute for Pure and Applied Mathematics, UCLA July 10, 2017 For more information: http://computationalgenomics.bioinformatics.ucla.edu/

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