Comparison of the Gene Expression Profiles Between Smokers With and Without Lung Cancer Using RNA-Seq

Lung cancer is the most common cause of cancer-related death in both men and women throughout the world. Cigarette smoke contains over 60 known carcinogens (Hech, 2003) and tobacco smoke is the main contributor to lung cancer (Biesalski et al., 1998) . Therefore, the tissues of those smokers with and without lung cancer provide great resources to study their gene expression changes and find out those lung cancer related genes to help corresponding treatment.

To better understand the gene expression differences between smokers with and without lung cancer, researchers at the Third Medical Military University, China analyzed two related datasets from short read archive (Beane, 2011).

They quantified the expression of human genes in these two samples of smokers with and without lung cancer. Differential expression analysis revealed a number of differentially expressed genes. The results show some interesting phenomenon of the gene expression profiles between smokers with and without lung cancer, and highlight that RNA-Seq technologies are powerful tools to study the characteristics of human transcriptome.

  • Cheng P, Cheng Y, Li Y, Zhao Z, Gao H, Li D, Li H, Zhang T. (2012) Comparison of the Gene Expression Profiles Between Smokers With and Without Lung Cancer Using RNA-Seq. Asian Pac J Cancer Prev13(8), 3605-9. [article]