Postdoctoral Researcher (Molecular Genetics) Primordial Dwarfism and Organism Growth
School of Molecular, Genetic and Population Health Sciences
£30,424 – £36,298
A postdoctoral researcher is sought for a three year post in Dr Andrew Jackson’s group to investigate the genetic basis of organism size.
For full advert details please visit: http://recruitment.mvm.ed.ac.uk/009884.pdf
The successful applicant will be involved in the identification of novel primordial dwarfism genes using NGS sequencing strategies. Exome (~150 patients) and RNAseq data is already available from our large cohort of patients with extreme growth reduction. Additionally, the postholder will investigate whether intermediate effect alleles in such genes are physiological determinants of body and brain size utilising available collaborator datasets and through their own resequencing studies. There will also be the opportunity to be involved in follow-up cellular and developmental functional studies.
The Jackson lab has identified 14 novel human disease genes within last 6 years (e.g. Nat Genet 38:910; 40:232; 43:350, 43:356), as well as a strong track record in functional analysis of disease genes using biochemical, structural, cellular and model organisms (Cell 149, 1008; J Cell Sci 120:3578. The goal of our work is to establish the molecular mechanisms underlying these conditions and provide new insights into biological processes and human disease pathogenesis.
Candidates must have a PhD or anticipate completing a PhD in the near future. You will need to demonstrate a strong track record and previous experience in molecular genetics. Candidates with next generation sequencing experience along with strong computational skills for the analysis of large genetic datasets are particularly encouraged to apply.
Lab website: http://www.ajackson.hgu.mrc.ac.uk
Closing date: 8 March 2013