Featured RNA-Seq Job – Senior Bioinformatician

rna-seqSalary £29,750 to £37,525 per annum depending on experience 

Fixed Term – 3 years

The Wellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to understanding gene function in health and disease.

We are seeking to appoint a Senior Bioinformatician to undertake analysis of a molecular phenotyping project using mice generated by the Mouse Genetics Project (MGP).  As part of the new Deciphering the Mechanisms of Developmental Disorders (DMDD) project we intend to implement a high-throughput mouse transcriptome profiling pipeline to run in parallel with a similar pipeline established in the Zebrafish Mutation Project (ZMP).  We would like to recruit an individual to develop the sample and data tracking system within the Mouse Informatics Group, process the sequence-based transcriptome profile data and develop analysis systems to exploit the transcript profiles using Gene Ontology to identify protein networks and pathways.

Job Family – Informatics
Job Reference – 81526

Essential Skills

  • Masters degree (or above) or equivalent experience in a relevant subject area (e.g. bioinformatics, computational biology, computer science)
  • Evidence of a high level of competence in Perl programming
  • Familiarity with developing in a UNIX/Linux environment
  • Experience and understanding of bioinformatics and familiarity with genome data
  • Ability to prioritise tasks to ensure the right things are done at the right time

Ideal Skills

  • Familiarity with Gene Ontology and associated tools
  • Background in statistical analyses, preferably using R

Other information

As part of a new strategic award, additional phenotyping tests in developmental biology (encompassing mouse embryonic days E9.5, E14.5 and E18.5) are to be undertaken, including 3D whole embryo imaging, placental histopathology, transcriptomics and nervous system functionality assessment. This award is directed by Prof Tim Mohun (NIMR, London) and will involve several research centres across the UK.


We offer a comprehensive range of benefits including a final salary pension scheme and excellent on-site facilities.

The Genome Campus is a 55-acre estate south of Cambridge in the grounds of Hinxton Hall. Nestled in the quiet countryside of these landscaped gardens, are two world-class research facilities: the Wellcome Trust Sanger Institute and the European Bioinformatics Institute (EBI). The site has become the British hub of biomedical science. The Campus is also home to the Wellcome Trust Advanced Courses and Scientific Conferences programme and the Wellcome Trust Conference Centre.

In addition to its peaceful location the campus offers excellent facilities including a state of the art data centre, gym, two cafes, a nursery, dining facilities, a cycle to work scheme, car sharing and free campus buses from various locations around Cambridge.

When applying please submit a CV and a covering letter.

Closing date for applications: 28 July 2013

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