Prostate cancer remains a leading cause of cancer morbidity and mortality in men, accounting for approximately one million new cases and 260 000 deaths per year worldwide. Incidence and mortality rates vary widely across geographic regions and ethnic groups. In particular, Asian populations have a substantially lower incidence rate than Caucasians or African Americans. The mechanism underlying these differences remains unclear.
In their recent study of prostate cancer in Chinese patients, Ren and colleagues used RNA-seq to profile genetic aberrations in 14 patient tumor versus adjacent normal tissues and confirmed their findings in an independent cohort of 54 patient tumor samples. Their results provided a global view of the transcriptome, identified tumor-associated gene fusions and somatic single nucleotide mutations, and monitored the expression of long non-coding RNAs and alternatively spliced genes.
This study yielded new insights into the pathogenesis of prostate cancer in the Chinese population.
See the review: Insights into Chinese prostate cancer with RNA-seq at Nature. com
- Ren S, Peng Z, Mao JH, Yu Y, Yin C, Gao X, Cui Z, Zhang J, Yi K, Xu W, Chen C, Wang F, Guo X, Lu J, Yang J, Wei M, Tian Z, Guan Y, Tang L, Xu C, Wang L, Gao X, Tian W, Wang J, Yang H, Wang J, Sun Y. (2012) RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings. Cell Res [Epub ahead of print]. [article]