Organisation: The Francis Crick Institute
Location: Midland Road, London
Contract: Fixed-Term (4 years), Full- time
Salary: Competitive with benefits, subject to skills and experience
Vacancy ID: 3042
The Francis Crick Institute (the Crick) is a research institute dedicated to discovering the fundamental biology underlying human health, with the aim of improving the diagnosis, treatment and prevention of human disease.
We are seeking a highly motivated and collaborative Postdoctoral Fellow to develop computational approaches for characterizing genome-wide changes to genetically modified embryos and embryonic stem cells using next generation sequencing. The fellow would also use computational approaches to understand the logic of signalling and transcriptional control in human embryos and stem cells.
We generate genome-wide data sets related to human embryo development and stem cell pluripotency, which require sophisticated computational analyses. The post-holder will develop computational and statistical methods necessary to characterise these data sets and to extract relevant biological information. The position will be based in Dr. Kathy Niakan’s laboratory.
PROJECT SCOPE/ DESCRIPTION
Dr Niakan’s laboratory focuses on understanding the mechanisms of lineage specification in human embryos and the establishment of novel human stem cells. Details of research projects currently being undertaken can be seen at: http://www.crick.ac.uk/kathy-niakan
Research techniques used in the laboratory include: next generation sequencing including whole genome sequencing, ChIP-sequencing and single-cell RNA-sequencing. The main strategies in the lab involve genomic profiling of early human embryos and microdissected cells and utilizing this data to inform novel strategies for stem cell derivation from embryos and reprogramming using induced pluripotent stem cell approaches. The post-holder will develop computational and statistical methods necessary to exploit these data sets and to extract relevant biological information.
There are opportunities to gain training in advanced human stem cell culture and molecular biology techniques, should this be of interest to the post-holder.
PLEASE NOTE: ALL OFFERS OF EMPLOYMENT ARE SUBJECT TO SUCCESSFUL SECURITY SCREENING AND CONTINUOUS ELIGIBILITY TO WORK IN THE UNITED KINGDOM.
For more information or if you are interested in applying for this role, please apply contact via our website https://www.jobs.crick.ac.uk.