By Vicki Glaser – Genetic Engineering News
Advanced Technological Approach Generates Genomic Data Better, Faster, and Cheaper
In the next-gen sequencing (NGS) arena, the focus over the past several years has been on technological advances, moving from second-generation to third-generation sequencing strategies and producing research instruments capable of delivering whole-genome sequences in parallel at increasing speed. More recently, as read lengths and coverage continue to increase, throughputs rise, and costs decline, the expanding range of applications of NGS has taken center stage.
…Genomic Health announced results from its next-gen sequencing-driven biomarker discovery program in breast cancer at the recent “Advances in Genome Biology and Technology” (AGBT) meeting. Based on sequencing of the whole human transcriptome in formalin-fixed paraffin-embedded (FFPE) tumor and normal breast tissue samples, the company found hundreds of differences in both coding and noncoding transcripts between the two sample populations. Genomic Health reported an association between specific genes and some non-coding RNAs and risk of breast cancer recurrence.