RNA-Seq contributes to comprehensive molecular characterization of human colon and rectal cancer

The Cancer Genome Atlas project plans to profile genomic changes in 20 different cancer types and has so far published results on two cancer types. They now present results from multidimensional analyses of human colorectal carcinoma (CRC). To characterize somatic alterations in colorectal carcinoma, they conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression.

The Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487, 330–337. [article]