Single-cell RNA-Seq Gaining Steam

rna-seq Single-cell RNA-Seq gives scientists unprecedented view of brain development (9/14/2018) - Detailed measurements of genes in individual brain cells allows scientists to trace specific developmental trajectories in the cerebellum Researchers at St. Jude Children’s Research Hospital have created a massive database of the changes in gene activity of individual cells in the cerebellum during embryonic development and immediately after birth. The analysis of thousands of brain ...
rna-seq A comprehensive single-cell analysis of airway cells reveals molecular details critical to understanding lung disease (8/6/2018) - Researchers have identified a rare cell type in airway tissue, previously uncharacterized in the scientific literature, that appears to play a key role in the biology of cystic fibrosis. Using new technologies that...
rna-seq STARmap – three-dimensional intact-tissue sequencing of single-cell transcriptional states (7/31/2018) - Retrieving high-content gene-expression information while retaining three-dimensional (3D) positional anatomy at cellular resolution has been difficult, limiting integrative understanding of structure and function in complex biological tissues. Stanford...
rna-seq netSmooth – network-smoothing based imputation for single cell RNA-seq (7/23/2018) - Single cell RNA-seq (scRNA-seq) experiments suffer from a range of characteristic technical biases, such as dropouts (zero or near zero counts) and high...
rna-seq dropEst – pipeline for accurate estimation of molecular counts in droplet-based single-cell RNA-seq experiments (7/16/2018) - Recent single-cell RNA-seq protocols based on droplet microfluidics use massively multiplexed barcoding to enable simultaneous measurements of transcriptomes for thousands of individual cells. The increasing complexity of such data creates challenges for subsequent computational processing...
rna-seq Recent developments in single-cell RNA-Seq of microorganisms (7/3/2018) - Single-cell transcriptome analysis through next-generation sequencing (single-cell RNA-seq) has been used broadly to address important biological questions. It has proved to be very powerful, and many exciting new biological discoveries have been achieved in the last decade. Its application has greatly improved our understanding of diverse biological processes and the underlying molecular mechanisms, an understanding ...
rna-seq Complex brain circuitry revealed using new single-cell sequencing technology (7/2/2018) - TGen and Circuit Therapeutics lead discoveries that could help patients with neuro-related conditions such as Parkinson’s and drug addiction...
rna-seq SAVER – gene expression recovery for single-cell RNA sequencing (6/28/2018) - In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts present in each cell are sequenced. This leads to unreliable...
rna-seq Gene expression distribution deconvolution in single-cell RNA sequencing (6/28/2018) - Single-cell RNA sequencing (scRNA-seq) enables the quantification of each gene’s expression distribution across cells, thus allowing the assessment of the...
Researchers develop a better method to compare gene expression in single cells (6/22/2018) - St. Jude Children’s Research Hospital investigators have developed a software package to help identify biomarkers that differentiate between cell...

A slew of recent high profile papers and upcoming conferences highlight the growing interest in single-cell transcriptomics.