Single-cell RNA-Seq Gaining Steam

rna-seq Dolomite Bio and Partek Collaborate on Single Cell Analysis Pipeline for Nadia Instrument (5/9/2018) - Dolomite Bio, a provider of high throughput single cell technology, and Partek Incorporated, a developer of genomic data analysis tools – today announced a collaboration to combine Partek’s single cell data analysis capabilities with Dolomite Bio’s microfluidic droplet-based single cell technology. Single cell data analysis enables researchers to gain useful insights into the diversity and ...
rna-seq Harvard scientists reveal the genetic roadmap to building an entire organism from a single cell (4/30/2018) - By KEVIN JIANG April 26, 2018 A zebrafish egg cell forms a complex embryo in only a few hours. Video by Fengzhu Xiong and Sean Megason Whether a worm, a human or a blue whale, all multicellular life begins as a single-celled egg. From this solitary cell emerges the galaxy of others needed to build an ...
rna-seq Norwich Single Cell Symposium 2018 (4/19/2018) - Start date: 16 May 2018 End date: 17 May 2018 Time: 09h00 – 17h00 Venue: Earlham Institute Organiser: Iain Macaulay Enquiries: training@earlham.ac.uk Registration deadline: 08 May 2018...
rna-seq VDJPuzzle – B-cell receptor reconstruction from single-cell RNA-seq (4/18/2018) - The B-cell receptor (BCR) performs essential functions for the adaptive immune system including recognition of pathogen-derived antigens. The vast repertoire and adaptive variation of BCR sequences due to V(D)J recombination and somatic...
rna-seq Single cell RNA-Seq technology and organoids reveal every bowel tumour and bowel cancer cell have unique genetic fingerprints (4/18/2018) - Study could help researchers target cancer-specific processes for cancer prevention or to develop treatments New research on bowel cancer has shown that every tumour is different, and that every cell within the tumour is also genetically unique. In the first study of its kind, researchers from the Wellcome Sanger Institute, UK and Hubrecht Institute (KNAW) ...
rna-seq FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data (4/11/2018) - To understand stem cell differentiation along multiple lineages, it is necessary to resolve heterogeneous cellular states and the ancestral relationships between them. Researchers from the Max Planck Institute of Immunobiology and Epigenetics developed a robotic miniaturized CEL-Seq2 implementation to carry out deep single-cell RNA-seq of ∼2,000 mouse hematopoietic progenitors enriched for lymphoid lineages, and used ...
rna-seq scmap – projection of single-cell RNA-seq data across data sets (4/5/2018) - Single-cell RNA-seq (scRNA-seq) allows researchers to define cell types on the basis of unsupervised clustering of the transcriptome. However, differences in experimental methods and computational analyses make it challenging to compare data across experiments. Wellcome Sanger Institute researchers present scmap, a method for projecting cells from an scRNA-seq data set onto cell types or individual ...
rna-seq Single-Cell RNA-Seq and cell heterogeneity in the central nervous system (4/5/2018) - Recent advances in single-cell RNA sequencing are producing exciting new insights into cell diversity within different tissues and cancers. Listen in to hear Dr Gonçalo Castelo-Branco and Dr Amit Zeisel, of the the Department of Medical Biochemistry...
rna-seq BEARscc determines robustness of single-cell clusters using simulated technical replicates (3/27/2018) - Single-cell messenger RNA sequencing (scRNA-seq) has emerged as a powerful tool to study cellular heterogeneity within complex tissues. Subpopulations of cells with common gene expression profiles can be identified by applying unsupervised clustering algorithms. However, technical variance is a major confounding factor in scRNA-seq, not least because it is not possible to replicate measurements on ...
rna-seq Transcriptome analysis – single cell RNA-Seq workflow (3/26/2018) - Single-cell analyses allow uncovering cellular heterogeneity, not only per se, but also in response to viral infection. Similarly, single cell transcriptome analyses (scRNA-Seq) can highlight specific...

A slew of recent high profile papers and upcoming conferences highlight the growing interest in single-cell transcriptomics.