Sperm RNA-seq Study Reveals Potential Biomarkers for Diagnosing Male Infertility

from GenomeWeb

NEW YORK (GenomeWeb) – Sperm RNA could be used as a biomarker diagnose male fertility, according to a new paper published today in Science Translational Medicine.

Scientists led by Meritxell Jodar and Stephen Krawetz of Wayne State University performed a retrospective RNA sequencing study on semen samples from both fertile and infertile men and discovered 648 sperm RNA elements (SREs) that they said are critically associated with male fertility.

“Current standard tests have a limited capacity to discern male factor infertility and thereby be predictive of fertility treatment success for couples presenting with idiopathic infertility,” the authors wrote. “The use of spermatozoal RNA [next-generation sequencing] identified a set of molecular biomarkers that shows potential to predict the success rate of fertility treatments.”

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