Tag Archives: alternative splicing

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51% of non-canonical splice sites are not annotated in GENCODE

51% of non-canonical splice sites are not annotated in GENCODE

Scientists at the Pontifical Catholic University of Chile have uncovered the diversity of non-canonical splice sites at the human transcriptome using deep transcriptome profiling. They mapped a total of 3.7 billion human RNA-seq reads and developed a set of stringent ...

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RNA-Seq a hot topic at last month’s ISMB conference

RNA-Seq a hot topic at last month’s ISMB conference

Poster – A50 Gene expression analyses of RNA-Sequencing data across multiple cancers to identify Basal-like cancer subtypes Kevin Thompson, Mayo Clinic, United States Xiaojia Tang, Mayo Clinic, United States Jason Sinwell, Mayo Clinic, United States Peter Vedell, Mayo Clinic, United ...

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The human skeletal muscle transcriptome

The human skeletal muscle transcriptome

Human skeletal muscle health is important for quality of life and several chronic diseases, including type II diabetes, heart disease, and cancer. Skeletal muscle is a tissue widely used to study mechanisms behind different diseases and adaptive effects of controlled ...

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ARH-seq – identification of differential splicing in RNA-seq data

ARH-seq – identification of differential splicing in RNA-seq data

The computational prediction of alternative splicing from high-throughput sequencing data is inherently difficult and necessitates robust statistical measures because the differential splicing signal is overlaid by influencing factors such as gene expression differences and simultaneous expression of multiple isoforms amongst ...

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High-resolution transcriptome analysis with long-read RNA sequencing

High-resolution transcriptome analysis with long-read RNA sequencing

RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput short-read sequencing of cDNA. However, as ongoing advances are rapidly yielding increasing ...

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