Tag Archives: alternative splicing

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The human skeletal muscle transcriptome

The human skeletal muscle transcriptome

Human skeletal muscle health is important for quality of life and several chronic diseases, including type II diabetes, heart disease, and cancer. Skeletal muscle is a tissue widely used to study mechanisms behind different diseases and adaptive effects of controlled ...

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ARH-seq – identification of differential splicing in RNA-seq data

ARH-seq – identification of differential splicing in RNA-seq data

The computational prediction of alternative splicing from high-throughput sequencing data is inherently difficult and necessitates robust statistical measures because the differential splicing signal is overlaid by influencing factors such as gene expression differences and simultaneous expression of multiple isoforms amongst ...

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High-resolution transcriptome analysis with long-read RNA sequencing

High-resolution transcriptome analysis with long-read RNA sequencing

RNA sequencing (RNA-seq) enables characterization and quantification of individual transcriptomes as well as detection of patterns of allelic expression and alternative splicing. Current RNA-seq protocols depend on high-throughput short-read sequencing of cDNA. However, as ongoing advances are rapidly yielding increasing ...

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Protein expression gets the heart pumping

Protein expression gets the heart pumping

HOUSTON – (April 22, 2014) – Most people think the development of the heart only happens in the womb, however the days and weeks following birth are full of cellular changes that play a role in the structure and function ...

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