Tag Archives: breast cancer

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Isoform-level gene expression patterns in single-cell RNA-sequencing data

Isoform-level gene expression patterns in single-cell RNA-sequencing data

RNA-sequencing of single-cells enables characterization of transcriptional heterogeneity in seemingly homogenous cell populations. In this study, reseachers from the Karolinska Institute propose and apply a novel method, ISOform-Patterns (ISOP), based on mixture modeling, to characterize the expression patterns of pairs ...

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RNA-Seq Identifies Gene Transcription Signatures that Predict Survival after Tamoxifen, CAF Chemotherapy

RNA-Seq Identifies Gene Transcription Signatures that Predict Survival after Tamoxifen, CAF Chemotherapy

from CanceTherapyAdvisor by Bryant Furlow SAN ANTONIO—Next generation whole-genome expression analysis with RNA sequencing (NGS) identified gene-expression biomarkers associated with survival among postmenopausal women with estrogen receptor-positive (ER+), node-positive breast cancer treated with tamoxifen or tamoxifen plus cyclophosphamide, dozorubicin (Adriamycin), ...

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BADGE – A novel Bayesian model for accurate abundance quantification and differential analysis of RNA-Seq data

BADGE – A novel Bayesian model for accurate abundance quantification and differential analysis of RNA-Seq data

Recent advances in RNA sequencing (RNA-Seq) technology have offered unprecedented scope and resolution for transcriptome analysis. However, precise quantification of mRNA abundance and identification of differentially expressed genes are complicated due to biological and technical variations in RNA-Seq data. Researchers ...

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OncoRep: An n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing

OncoRep: An n-of-1 reporting tool to support genome-guided treatment for breast cancer patients using RNA-sequencing

Breast cancer comprises multiple tumor entities associated with different biological features and clinical behaviors, making individualized medicine a powerful tool to bring the right drug to the right patient. Next generation sequencing of RNA (RNA-Seq) is a suitable method to ...

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