Tag Archives: breast cancer

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RNA sequencing of cancer reveals novel splicing alterations

Breast cancer transcriptome acquires a myriad of regulation changes, and splicing is critical for the cell to “tailor-make” specific functional transcripts. Researchers at The George Washington University systematically revealed splicing signatures of the three most common types of breast tumors ...

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The Breast Cancer Landscape

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups The elucidation of breast cancer subgroups and their molecular drivers requires integrated views of the genome and transcriptome from representative numbers of patients. A team led by researchers ...

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RNA-Seq faces a tough road to the cancer clinic

Despite the development of molecular classifications, and prognostic and predictive gene-expression signatures, microarray-based studies have not yielded definitive answers to many of the questions that remain germane for the successful implementation of personalized medicine. Similar challenges are likely to be ...

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Combined use of Exome and Transcriptome Sequencing

To identify potential tumor suppressor genes, genome-wide data from exome and transcriptome sequencing were combined to search for genes with loss of heterozygosity and allele-specific expression. The analysis was conducted on the breast cancer cell line HCC1954, and a lymphoblast ...

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