Tag Archives: gene expression

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The Impact of Normalization Methods on RNA-Seq Data Analysis

The Impact of Normalization Methods on RNA-Seq Data Analysis

High-throughput sequencing technologies, such as the Illumina Hi-seq, are powerful new tools for investigating a wide range of biological and medical problems. Massive and complex data sets produced by the sequencers create a need for development of statistical and computational ...

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PAT-seq – genome wide 3′-UTR dynamics

PAT-seq – genome wide 3′-UTR dynamics

A major objective of systems biology is to quantitatively integrate multiple parameters from genome-wide measurements. To integrate gene expression with dynamics in poly(A) tail length and adenylation site, researchers at Monash University developed a targeted next-generation sequencing approach, Poly(A)-Test RNA-sequencing. ...

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