Tag Archives: high-throughput sequencing

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High-throughput sequencing for the study of bacterial pathogen biology

High-throughput sequencing for the study of bacterial pathogen biology

A revolution in sequencing technologies in recent years has led to dramatically increased throughput and reduced cost of bacterial genome sequencing. An increasing number of applications of the new technologies are providing broad insights into bacterial evolution, epidemiology, and pathogenesis. ...

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DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets

DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets

To identify physiological targets of drugs and bioactive small molecules, researchers at The Rockefeller University developed an approach, named DrugTargetSeqR, which combines high-throughput sequencing, computational mutation discovery and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-based genome editing. They applied this ...

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ARH-seq – identification of differential splicing in RNA-seq data

ARH-seq – identification of differential splicing in RNA-seq data

The computational prediction of alternative splicing from high-throughput sequencing data is inherently difficult and necessitates robust statistical measures because the differential splicing signal is overlaid by influencing factors such as gene expression differences and simultaneous expression of multiple isoforms amongst ...

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