Tag Archives: high-throughput sequencing

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DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets

DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets

To identify physiological targets of drugs and bioactive small molecules, researchers at The Rockefeller University developed an approach, named DrugTargetSeqR, which combines high-throughput sequencing, computational mutation discovery and clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9-based genome editing. They applied this ...

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ARH-seq – identification of differential splicing in RNA-seq data

ARH-seq – identification of differential splicing in RNA-seq data

The computational prediction of alternative splicing from high-throughput sequencing data is inherently difficult and necessitates robust statistical measures because the differential splicing signal is overlaid by influencing factors such as gene expression differences and simultaneous expression of multiple isoforms amongst ...

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