Tag Archives: isomirs

IsomiR Bank – a research resource for tracking IsomiRs

rna-seq

Next-Generation Sequencing (NGS) technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent differences from their corresponding mature reference sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). These isomiRs mainly originate via the imprecise and alternative cleavage during ...

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MIRPIPE – quantification of microRNAs in niche model organisms

rna-seq

MicroRNAs represent an important class of small non-coding RNAs regulating gene expression in eukaryotes. Present algorithms typically rely on genomic data to identify miRNAs and require extensive installation procedures. Niche model organisms lacking genomic sequences cannot be analyzed by such ...

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Hypoxic signature of microRNAs in glioblastoma: insights from small RNA deep sequencing

rna-seq

Hypoxia is a critical aspect of the glioma microenvironment and has been associated with poor prognosis and resistance to various therapies. However, the mechanisms responsible for hypoxic survival of glioma cells remain unclear. Recent studies strongly suggest that microRNAs act ...

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New Technologies Reveal the Porcine microRNAome

The development of next generation technologies is enabling the complete mapping and further understanding of microRNAs (miRNAs).  Deep sequencing (NGS) provides complete coverage of the small transcriptome and new bioinformatics tools such as ACGT101-miR enable an exhaustive analysis of the ...

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