Tag Archives: microarray

Strategies to Identify Natural Antisense Transcripts

rna-seq

Natural antisense transcripts, originally considered as transcriptional noises arising from so-called “junk DNA”, are recently recognized as important modulators for gene regulation. They are prevalent in nearly all realms of life and have been found to modulate gene expression positively ...

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University of Cambridge researchers describe new method for revealing short-term changes in gene expression, alterations in RNA decay rates, and the kinetics of RNA processing

rna-seq

Cellular RNA levels are orchestrated by highly regulated processes involving RNA synthesis (transcription), processing (e.g., splicing, polyadenylation, transport), and degradation. Profiling these changes provides valuable information on the regulation of gene expression. Total cellular RNA is a poor template for ...

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Mapping eQTLs With RNA-Seq reveals a more comprehensive set of eQTLs and illuminates underlying molecular consequence missed by microarrays

Studies attempting to functionally interpret complex-disease susceptibility loci by GWAS and eQTL integration have predominantly employed microarrays to quantify gene-expression. RNA-Seq has the potential to discover a more comprehensive set of eQTLs and illuminate the underlying molecular consequence. Researchers from ...

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GOexpress – an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers. While integration of differential expression statistics has been used to refine ...

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