Tag Archives: microrna

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An evaluation of microRNA alignment techniques

An evaluation of microRNA alignment techniques

Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses considerable challenges due to their short length (∼21 nucleotides [nt]) as well as the large size and complexity of plant and animal genomes. While several tools have been developed ...

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Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. ...

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TarPmiR – a new approach for microRNA target site prediction

TarPmiR – a new approach for microRNA target site prediction

The identification of microRNA (miRNA) target sites is fundamentally important for studying gene regulation. There are dozens of computational methods available for miRNA target site prediction. Despite their existence, we still cannot reliably identify miRNA target sites, partially due to ...

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Improving microRNA target prediction with gene expression profiles

Improving microRNA target prediction with gene expression profiles

Mammalian genomes encode for thousands of microRNAs, which can potentially regulate the majority of protein-coding genes. They have been implicated in development and disease, leading to great interest in understanding their function, with computational methods being widely used to predict ...

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