Tag Archives: microrna

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Improving microRNA target prediction with gene expression profiles

Improving microRNA target prediction with gene expression profiles

Mammalian genomes encode for thousands of microRNAs, which can potentially regulate the majority of protein-coding genes. They have been implicated in development and disease, leading to great interest in understanding their function, with computational methods being widely used to predict ...

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Fighting veterinary drug abuse with RNA-Seq

Fighting veterinary drug abuse with RNA-Seq

Worldwide growth and performance-enhancing substances are used in cattle husbandry to increase productivity. In certain countries however e.g., in the EU, these practices are forbidden to prevent the consumers from potential health risks of substance residues in food. To maximize ...

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miTALOS v2 – Analyzing Tissue Specific microRNA Function

miTALOS v2 – Analyzing Tissue Specific microRNA Function

MicroRNAs are involved in almost all biological processes and have emerged as regulators of signaling pathways. Researchers from the German Research Center for Environmental Health show that miRNA target genes and pathway genes are not uniformly expressed across human tissues. To ...

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The dark matter of the cancer genome has been largely neglected

The dark matter of the cancer genome has been largely neglected

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor-specific mutations not only in protein-coding sequences but also in non-coding ...

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Bioinformatics Resources for MicroRNA Discovery

Bioinformatics Resources for MicroRNA Discovery

Biomarker identification is often associated with the diagnosis and evaluation of various diseases. Recently, the role of microRNA (miRNA) has been implicated in the development of diseases, particularly cancer. With the advent of next-generation sequencing, the amount of data on ...

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