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Small-RNA Sequencing of Single Cells

Small-RNA Sequencing of Single Cells

The ability to profile mRNAs in single cells has transformed the molecular identification and the characterization of cell types, states and rare cellular phenotypes. However, current single-cell methods are restricted to long RNAs, primarily mRNAs. Several classes of small RNAs ...

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A workflow for analysis of small RNA sequencing data

A workflow for analysis of small RNA sequencing data

Small RNAs (size 20-30 nt) of various types have been actively investigated in recent years, and their subcellular compartmentalization and relative concentrations are likely to be of importance to their cellular and physiological functions. Comprehensive data on this subset of ...

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gsa4mirna – Integrated gene set analysis for microRNA studies

gsa4mirna – Integrated gene set analysis for microRNA studies

Functional interpretation of miRNA expression data is currently done in a three step procedure: select differentially expressed miRNAs, find their target genes, and carry out gene set overrepresentation analysis Nevertheless, major limitations of this approach have already been described at ...

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Upcoming Webinar – Profiling microRNA from single cells

Upcoming Webinar – Profiling microRNA from single cells

Performing qPCR-based profiling of microRNA from single cells or small cell numbers? Our July 12 webinar will definitely help you get the most out of your precious samples! The webinar focuses on a new, streamlined process for differential expression profiling based on ...

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Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. ...

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