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Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Recommendations for differential expression analysis and biomarker discovery small RNA-Seq experiments in an age of liquid biopsies

Small RNA-Seq has emerged as a powerful tool in transcriptomics, gene expression profiling and biomarker discovery. Sequencing cell-free nucleic acids, particularly microRNA (miRNA), from liquid biopsies additionally provides exciting possibilities for molecular diagnostics, and might help establish disease-specific biomarker signatures. ...

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Fighting veterinary drug abuse with RNA-Seq

Fighting veterinary drug abuse with RNA-Seq

Worldwide growth and performance-enhancing substances are used in cattle husbandry to increase productivity. In certain countries however e.g., in the EU, these practices are forbidden to prevent the consumers from potential health risks of substance residues in food. To maximize ...

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miTALOS v2 – Analyzing Tissue Specific microRNA Function

miTALOS v2 – Analyzing Tissue Specific microRNA Function

MicroRNAs are involved in almost all biological processes and have emerged as regulators of signaling pathways. Researchers from the German Research Center for Environmental Health show that miRNA target genes and pathway genes are not uniformly expressed across human tissues. To ...

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DASHR – a database of small human noncoding RNAs

DASHR – a database of small human noncoding RNAs

Small non-coding RNAs (sncRNAs) are highly abundant RNAs, typically <100 nucleotides long, that act as key regulators of diverse cellular processes. Although thousands of sncRNA genes are known to exist in the human genome, no single database provides searchable, unified ...

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