Tag Archives: next-generation sequencing

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Scrimer – designing primers from transcriptome data

Scrimer – designing primers from transcriptome data

With the rise of next-generation sequencing methods it has become increasingly possible to obtain genome-wide sequence data even for non-model species. Such data are often used for the development of single nucleotide polymorphism (SNP) markers, which can subsequently be screened ...

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Using REDItools to Detect RNA Editing Events in NGS Datasets

Using REDItools to Detect RNA Editing Events in NGS Datasets

RNA editing is a post-transcriptional/co-transcriptional molecular phenomenon whereby a genetic message is modified from the corresponding DNA template by means of substitutions, insertions, and/or deletions. It occurs in a variety of organisms and different cellular locations through evolutionally and biochemically ...

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Could RNA-Seq Become the Workhorse of Precision Medicine?

Could RNA-Seq Become the Workhorse of Precision Medicine?

from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D. Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique Advances in genomics over the past several years have had a profound impact on our grasp of molecular biology and genetics. ...

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Considerations for RNA-Seq Analysis of Circadian Rhythms

Considerations for RNA-Seq Analysis of Circadian Rhythms

Circadian rhythms are daily endogenous oscillations of behavior, metabolism, and physiology. At a molecular level, these oscillations are generated by transcriptional-translational feedback loops composed of core clock genes. In turn, core clock genes drive the rhythmic accumulation of downstream outputs-termed ...

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Microarray Not Fade Away

Microarray Not Fade Away

Yes, many are attracted to next-generation sequencing, but loyalty to chip-based phenotyping has its rewards, particularly in screens of large sample sets. from Genetic Engineering News – by Lisa Heiden The microarray, the legacy technology for measuring gene expression, will ...

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