Tag Archives: next-generation sequencing

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Post-doc position available – single-cell technologies

Post-doc position available – single-cell technologies

Job Summary Performs basic research duties under the supervision/direction of a Physician (Principal Investigator). DUTIES AND RESPONSIBILITIES Research in bioinformatics interested in developing statistical methods and computational algorithms to interpret next-generation sequencing data. This candidate will combine epigenomics, transcriptome, and ...

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RNA-Seq as a Tool to Study the Tumor Microenvironment

RNA-Seq as a Tool to Study the Tumor Microenvironment

The transcriptome is composed of different types of RNA molecules including mRNAs, tRNAs, rRNAs, and other noncoding RNAs that are found inside a cell at a given time. Analyzing transcriptome patterns can shed light on the functional state of the ...

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rG4-seq – a new method for RNA G-quadruplex (rG4) transcriptome profiling

rG4-seq – a new method for RNA G-quadruplex (rG4) transcriptome profiling

Researchers from the University of Cambridge introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling with next-generation sequencing. Using rG4-seq on polyadenylated-enriched HeLa RNA, the researchers generated a global in vitro ...

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Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to ...

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An evaluation of microRNA alignment techniques

An evaluation of microRNA alignment techniques

Genomic alignment of small RNA (smRNA) sequences such as microRNAs poses considerable challenges due to their short length (∼21 nucleotides [nt]) as well as the large size and complexity of plant and animal genomes. While several tools have been developed ...

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The FDA weighs in on RNA-Seq

The FDA weighs in on RNA-Seq

The rapid advancement of emerging genomics technologies and their application for assessing safety and efficacy of FDA-regulated products require a high standard of reliability and robustness supporting regulatory decision-making in the FDA. To facilitate the regulatory application, the FDA implemented ...

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IsomiR Bank – a research resource for tracking IsomiRs

IsomiR Bank – a research resource for tracking IsomiRs

Next-Generation Sequencing (NGS) technology has revealed that microRNAs (miRNAs) are capable of exhibiting frequent differences from their corresponding mature reference sequences, generating multiple variants: the isoforms of miRNAs (isomiRs). These isomiRs mainly originate via the imprecise and alternative cleavage during ...

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