Tag Archives: next-generation sequencing

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The PARA-suite – PAR-CLIP specific sequence read simulation and processing

The PARA-suite – PAR-CLIP specific sequence read simulation and processing

Next-generation sequencing technologies have profoundly impacted biology over recent years. Experimental protocols, such as photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation (PAR-CLIP), which identifies protein-RNA interactions on a genome-wide scale, commonly employ deep sequencing. With PAR-CLIP, the incorporation of photoactivatable nucleosides into ...

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Post-doc position available – single-cell technologies

Post-doc position available – single-cell technologies

Job Summary Performs basic research duties under the supervision/direction of a Physician (Principal Investigator). DUTIES AND RESPONSIBILITIES Research in bioinformatics interested in developing statistical methods and computational algorithms to interpret next-generation sequencing data. This candidate will combine epigenomics, transcriptome, and ...

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RNA-Seq as a Tool to Study the Tumor Microenvironment

RNA-Seq as a Tool to Study the Tumor Microenvironment

The transcriptome is composed of different types of RNA molecules including mRNAs, tRNAs, rRNAs, and other noncoding RNAs that are found inside a cell at a given time. Analyzing transcriptome patterns can shed light on the functional state of the ...

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rG4-seq – a new method for RNA G-quadruplex (rG4) transcriptome profiling

rG4-seq – a new method for RNA G-quadruplex (rG4) transcriptome profiling

Researchers from the University of Cambridge introduce RNA G-quadruplex sequencing (rG4-seq), a transcriptome-wide RNA G-quadruplex (rG4) profiling method that couples rG4-mediated reverse transcriptase stalling with next-generation sequencing. Using rG4-seq on polyadenylated-enriched HeLa RNA, the researchers generated a global in vitro ...

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Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to ...

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