Tag Archives: next-generation sequencing

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Tools for small RNA biomarker discovery using RNA-Seq

Tools for small RNA biomarker discovery using RNA-Seq

Small ncRNAs (sncRNAs) offer great hope as biomarkers of disease and response to treatment. This has been highlighted in the context of several medical conditions such as cancer, liver disease, cardiovascular disease, and central nervous system disorders, among many others. ...

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Desperately Seq’ing RNA

Desperately Seq’ing RNA

from Genetic Engineering News by Vicki Glaser Next-Generation Sequencing Is Increasingly Making Headway in Clinical Medicine for Diagnostic and Prognostic Purposes It’s early days, but next-generation sequencing (NGS) is increasingly making headway in clinical medicine for diagnostic and prognostic purposes, for ...

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HeLa RNA is everywhere

HeLa RNA is everywhere

from the Virology Blog By Vincent Racaniello The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon ...

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Scrimer – designing primers from transcriptome data

Scrimer – designing primers from transcriptome data

With the rise of next-generation sequencing methods it has become increasingly possible to obtain genome-wide sequence data even for non-model species. Such data are often used for the development of single nucleotide polymorphism (SNP) markers, which can subsequently be screened ...

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Using REDItools to Detect RNA Editing Events in NGS Datasets

Using REDItools to Detect RNA Editing Events in NGS Datasets

RNA editing is a post-transcriptional/co-transcriptional molecular phenomenon whereby a genetic message is modified from the corresponding DNA template by means of substitutions, insertions, and/or deletions. It occurs in a variety of organisms and different cellular locations through evolutionally and biochemically ...

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Could RNA-Seq Become the Workhorse of Precision Medicine?

Could RNA-Seq Become the Workhorse of Precision Medicine?

from Genetic Engineering News by Jeffrey S. Buguliskis, Ph.D. Plowing through Transcriptional Variations by Harnessing the Powerful Next-Gen Technique Advances in genomics over the past several years have had a profound impact on our grasp of molecular biology and genetics. ...

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Considerations for RNA-Seq Analysis of Circadian Rhythms

Considerations for RNA-Seq Analysis of Circadian Rhythms

Circadian rhythms are daily endogenous oscillations of behavior, metabolism, and physiology. At a molecular level, these oscillations are generated by transcriptional-translational feedback loops composed of core clock genes. In turn, core clock genes drive the rhythmic accumulation of downstream outputs-termed ...

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