Tag Archives: RNA-Seq

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scphaser – haplotype inference using single-cell RNA-seq data

scphaser – haplotype inference using single-cell RNA-seq data

Determination of haplotypes is important for modelling the phenotypic consequences of genetic variation in diploid organisms, including cis-regulatory control and compound heterozygosity. Karolinska Institute researchers realized that single cell RNA-seq (scRNA-seq) data is well suited for phasing genetic variants, since ...

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An Integrated Approach for RNA-seq Data Normalization

An Integrated Approach for RNA-seq Data Normalization

DNA copy number alteration is common in many cancers. Studies have shown that insertion or deletion of DNA sequences can directly alter gene expression, and significant correlation exists between DNA copy number and gene expression. Data normalization is a critical ...

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