Tag Archives: RNA-Seq

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HeLa RNA is everywhere

HeLa RNA is everywhere

from the Virology Blog By Vincent Racaniello The first immortal human cell line ever produced, HeLa, originated from a cervical adenocarcinoma taken from Henrietta Lacks. The cell line grew so well that it was used in many laboratories and soon ...

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RNA Sequencing and the Evolution of Plants

RNA Sequencing and the Evolution of Plants

Many phylogenomic studies based on transcriptomes have been limited to “single-copy” genes due to methodological challenges in homology and orthology inferences. Only a relatively small number of studies have explored analyses beyond reconstructing species relationships. A multi-national team led by ...

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The impact of quality filter for RNA-Seq

The impact of quality filter for RNA-Seq

With the emergence of large-scale sequencing platforms since 2005, there has been a great revolution regarding methods for decoding DNA sequences, which have also affected quantitative and qualitative gene expression analyses through the RNA-Sequencing technique. However, issues related to the ...

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A comparative study of RNA-seq analysis strategies

A comparative study of RNA-seq analysis strategies

Three principal approaches have been proposed for inferring the set of transcripts expressed in RNA samples using RNA-seq. The simplest approach uses curated annotations, which assumes the transcripts in a sample are a subset of the transcripts listed in a ...

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Using REDItools to Detect RNA Editing Events in NGS Datasets

Using REDItools to Detect RNA Editing Events in NGS Datasets

RNA editing is a post-transcriptional/co-transcriptional molecular phenomenon whereby a genetic message is modified from the corresponding DNA template by means of substitutions, insertions, and/or deletions. It occurs in a variety of organisms and different cellular locations through evolutionally and biochemically ...

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