Tag Archives: RNA-Seq

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Characterization of human plasma-derived exosomal RNAs by RNA-Seq

Exosomes, endosome-derived membrane microvesicles, contain specific RNA transcripts that are thought to be involved in cell-cell communication. These RNA transcripts have great potential as disease biomarkers. To characterize exosomal RNA profiles systemically, a team led by researchers at the Medical ...

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Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microrna expression patterns and candidate novel microRNAs differentially expressed upon infection

New sequencing technologies allow unprecedented views into changes occurring in virus-infected cells, including comprehensive and largely unbiased measurements of different types of RNA. In this study, researchers from the University of Washington used RNA-Seq to profile dynamic changes in cellular ...

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Are all of the human exons alternatively spliced?

Alternative mRNA splicing (AS) is a major mechanism for increasing regulatory complexity. A key concept in AS is the distinction between alternatively and constitutively spliced exons (ASEs and CSEs, respectively). ASEs and CSEs have been reported to be differentially regulated, ...

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Differential Expression Analysis of RNA-Seq Data

Differential Expression Analysis of RNA-Seq Data

from BioCompare by Josh P. Roberts Knowledge of gene expression is crucial to understanding the molecular underpinnings of biology and medicine. As our ability to query the transcriptome grows—as new instrumentation comes online and becomes refined, along with the techniques ...

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