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Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor Heterogeneity, Single-Cell Sequencing, and Drug Resistance

Tumor heterogeneity has been compared with Darwinian evolution and survival of the fittest. The evolutionary ecosystem of tumors consisting of heterogeneous tumor cell populations represents a considerable challenge to tumor therapy, since all genetically and phenotypically different subpopulations have to ...

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RNA-Seq reveals shortcomings of experimentation models

RNA-Seq reveals shortcomings of experimentation models

Microglia are resident myeloid cells in the CNS that are activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been the primary in vitro models used to study neuroinflammation for more than a decade because they ...

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RNA Sequencing – Technologies and Global Markets

RNA Sequencing – Technologies and Global Markets

LONDON, June 6, 2016 /PRNewswire/ — This BCC Research report provides an overview of the current and future states of the RNA Sequencing (RNA Seq) market for the years 2015, 2016 and 2020 in segments such as instruments, tools and ...

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GOexpress – an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

GOexpress – an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers. While integration of differential expression statistics has been used to refine ...

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Identification of novel long non-coding RNAs using RNA-Seq

Identification of novel long non-coding RNAs using RNA-Seq

Functional characterization of long non-coding RNAs (lncRNAs) and their pathological relevance is still a challenging task. Abnormal expression of a few long non-coding RNAs have been found associated with hepatocellular carcinoma, with potential implications to both improve our understanding of ...

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