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RNA-Seq reveals shortcomings of experimentation models

RNA-Seq reveals shortcomings of experimentation models

Microglia are resident myeloid cells in the CNS that are activated by infection, neuronal injury, and inflammation. Established BV2 microglial cell lines have been the primary in vitro models used to study neuroinflammation for more than a decade because they ...

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RNA Sequencing – Technologies and Global Markets

RNA Sequencing – Technologies and Global Markets

LONDON, June 6, 2016 /PRNewswire/ — This BCC Research report provides an overview of the current and future states of the RNA Sequencing (RNA Seq) market for the years 2015, 2016 and 2020 in segments such as instruments, tools and ...

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GOexpress – an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

GOexpress – an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data

Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers. While integration of differential expression statistics has been used to refine ...

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Identification of novel long non-coding RNAs using RNA-Seq

Identification of novel long non-coding RNAs using RNA-Seq

Functional characterization of long non-coding RNAs (lncRNAs) and their pathological relevance is still a challenging task. Abnormal expression of a few long non-coding RNAs have been found associated with hepatocellular carcinoma, with potential implications to both improve our understanding of ...

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RNA sequencing of the nephron transcriptome: a technical note

RNA sequencing of the nephron transcriptome: a technical note

To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool. RNA sequencing (RNA-seq) has revolutionized transcriptomic research, enabling researchers to define transcription activity and ...

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RNA sequencing set to change cancer diagnosis in India

RNA sequencing set to change cancer diagnosis in India

According to Jain, in case of lung Cancer merely 6-9 genes are tested to diagnose, but RNA sequencing tests 25,000 genes, which takes to accurate diagnosis. In India nearly 75,000 new lung Cancer cases are reported each year. With increasing ...

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The power and promise of RNA-seq in ecology and evolution

The power and promise of RNA-seq in ecology and evolution

Reference is regularly made to the power of new genomic sequencing approaches. Using powerful technology, however, is not the same as having the necessary power to address a research question with statistical robustness. In the rush to adopt new and ...

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