Tag Archives: sequencing

Simultaneous sequencing of the genome and transcriptome at the single-cell level is a powerful tool for characterizing genomic and transcriptomic variation and revealing correlative relationships...

The recently introduced Kallisto pseudoaligner has radically simplified the quantification of transcripts in RNA-sequencing experiments.  Researchers from the Keck School of Medicine of USC offer cloud-scale RNAseq pipelines Arkas-Quantification, which deploys Kallisto for parallel cloud computations, and Arkas-Analysis, which annotates ...

News Medical Life Sciences by By Catherine Shaffer, M.Sc. – If DNA is the fundamental code of the genome, RNA is the message. Genes are made active through the process of transcribing the code into RNA, and then translating RNA into DNA. This is known as ...

Grafting of cell lines and primary tumours is a crucial step in the drug development process between cell line studies and clinical trials. AstraZeneca researchers have developed disambiguate, a program for computationally separating the sequencing reads of two species derived ...

Next-generation sequencing (NGS) informs many biological questions with unprecedented depth and nucleotide resolution. These assays have created a need for analytical tools that enable users to manipulate data nucleotide-by-nucleotide robustly and easily. Furthermore, because many NGS assays encode information jointly ...

RNA-Seq is the leading technology for analyzing gene expression on a global scale across a broad spectrum of sample types. However, due to chemical modifications by fixation or degradation due to collection methods, samples often contain an abundance of RNA ...

Large-scale sequencing experiments are complex and require a wide spectrum of computational tools to extract and interpret relevant biological information. This is especially true in projects where individual processing and integrated analysis of both small RNA and complementary RNA data ...

Microarray (MA) and high-throughput sequencing are two commonly used detection systems for global gene expression profiling. Although these two systems are frequently used in parallel, the differences in their final results had not to be examined thoroughly. Transcriptomic analysis of ...

Sequencing of RNA (RNA-seq) is a recent technique that emerged shortly after next-generation sequencing (NGS) was invented approx. 10 years ago and since has revolutionized biological research in the 21st century. The major advance and basis of NGS is the ...

Job ID – 2015-1256 # of Openings – 1 Job Locations – US-MA-Cambridge Posted Date – 8/10/2015 Category – Research & Development Overview: Foundation Medicine is seeking a talented, highly motivated and results-oriented Scientist to join the Molecular Biology and ...