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Optimizing RNA-Seq Mapping with STAR

Optimizing RNA-Seq Mapping with STAR

Sequencing of transcribed RNA molecules (RNA-seq) is an invaluable tool for studying cell transcriptomes at high resolution and depth. RNA-seq datasets typically consist of tens to hundreds of millions of relatively short (30–200 nt) sequence fragments of the original RNA ...

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Deciphering the Cancer Transcriptome

Deciphering the Cancer Transcriptome

from Genetic Engineering News by Richard A. Stein – In recent years, scientists have adopted a gene-centric view of cancer, a tendency to see each malignant transformation as the consequence of alterations in a discrete number of genes or pathways. ...

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Penn Researchers Illuminate “Dark Side” of the Transcriptome

Penn Researchers Illuminate “Dark Side” of the Transcriptome

New approach to quantifying gene “read-outs” reveals important variations in protein synthesis and has implications for understanding neurodegenerative diseases PHILADELPHIA— A new way of mapping the “transcriptome” — the collection of RNA read-outs that are expressed by a cell’s active ...

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RNA sequencing of the nephron transcriptome: a technical note

RNA sequencing of the nephron transcriptome: a technical note

To understand the functions of the kidney, the transcriptome of each part of the nephron needs to be profiled using a highly sensitive and unbiased tool. RNA sequencing (RNA-seq) has revolutionized transcriptomic research, enabling researchers to define transcription activity and ...

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Review – RNA-Seq and Horse Racing

Review – RNA-Seq and Horse Racing

RNA sequencing (RNA-seq) by next-generation technology is a powerful tool which creates new possibilities in whole-transcriptome analysis. In recent years, with the use of the RNA-seq method, several studies expanded transcriptional gene profiles to understand interactions between genotype and phenotype, ...

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