Tag Archives: transcriptomics

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Single cell transcriptomics of the human endocrine pancreas

Single cell transcriptomics of the human endocrine pancreas

Human pancreatic islets consist of multiple endocrine cell types. To facilitate the detection of rare cellular states and uncover population heterogeneity, UPENN School of Medicine researchers performed single-cell RNA-sequencing on islets from multiple deceased organ donors, including children, healthy adults, ...

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Fighting veterinary drug abuse with RNA-Seq

Fighting veterinary drug abuse with RNA-Seq

Worldwide growth and performance-enhancing substances are used in cattle husbandry to increase productivity. In certain countries however e.g., in the EU, these practices are forbidden to prevent the consumers from potential health risks of substance residues in food. To maximize ...

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The potential of single-cell transcriptomics in plants

The potential of single-cell transcriptomics in plants

Single-cell RNA-seq works as efficiently in plant cells as in animal cells. Noise profiles are well understood and an early set of analytical approaches is now capable of extracting information not previously possible in pooled samples. The biggest technical challenges ...

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BBBomics – Human Blood Brain Barrier Transcriptomics Hub

BBBomics – Human Blood Brain Barrier Transcriptomics Hub

Blood-brain barrier (BBB) is a monolayer of endothelial cells that line brain capillaries. The BBB protects brain by blocking the entry of harmful substances from blood and shielding the brain from peripheral fluctuations in hormones, fatty acids, and electrolytes. In ...

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Don’t bother with transcript level analysis

Don’t bother with transcript level analysis

High-throughput sequencing of cDNA (RNA-seq) is used extensively to characterize the transcriptome of cells. Many transcriptomic studies aim at comparing either abundance levels or the transcriptome composition between given conditions, and as a first step, the sequencing reads must be ...

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RNA-Seq Improves the Giant Panda Genome

RNA-Seq Improves the Giant Panda Genome

High-quality and complete gene models are the basis of whole genome analyses. The giant panda (Ailuropoda melanoleuca) genome was the first genome sequenced on the basis of solely short reads, but the genome annotation had lacked the support of transcriptomic ...

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Advancements in RNA-Seq Time Course and Downstream Analysis

Advancements in RNA-Seq Time Course and Downstream Analysis

Analysis of gene expression has contributed to a plethora of biological and medical research studies. Microarrays have been intensively used for the profiling of gene expression during diverse developmental processes, treatments and diseases. New massively parallel sequencing methods, often named ...

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