Tag Archives: University of Pennsylvania

Advancements in sequencing technologies have highlighted the role of alternative splicing (AS) in increasing transcriptome complexity. This role of AS, combined with the relation of aberrant splicing to malignant states, motivated two streams of research, experimental and computational. The first ...

Large compendia of gene expression data have proven valuable for the discovery of novel biological relationships. The majority of available RNA assays are run on microarray, while RNA-seq is becoming the platform of choice for new experiments. The data structure ...

Allele-specific expression is traditionally studied by bulk RNA sequencing, which measures average expression across cells. Single-cell RNA sequencing (scRNA-seq) allows the comparison of expression distribution between the two alleles of a diploid organism and thus the characterization of allele-specific bursting. ...

A key component in many RNA-Seq based studies is the production of multiple replicates for varying experimental conditions. Such replicates allow to capture underlying biological variability and control for experimental ones. However, during data production researchers often lack clear definitions ...

Alignment is the first step in most RNA-seq analysis pipelines, and the accuracy of downstream analyses depends heavily on it. Unlike most steps in the pipeline, alignment is particularly amenable to benchmarking with simulated data. Researchers from the University of ...

The goal is to make it easier for science teachers to incorporate the latest advances in science into their curricula. The initiative, Discovering the Genome, was spearheaded by Kristin Field, director of programs at Penn’s Nano/Bio Interface Center, and Junhyong ...

Support-limb laminitis was the type of laminitis 2006 Kentucky Derby winner Barbaro (seen here at the University of Pennsylvania’s New Bolton Center) succumbed to while healing from a severe fracture in a hind limb. The American Association of Equine Practitioners ...

Since it launched in 2013, the Center for Personalized Diagnostics at the University of Pennsylvania Health System has sequenced more than 4,000 clinical tumor samples to help provide actionable genomic data for the treatment of a variety of cancers. In ...

Highlights    Defined open chromatin regions in sorted human α- and β-cells using ATAC-seq.    Detected type 2 diabetes-associated risk loci in human α- and β-cell open chromatin.    Classified human α- and β-cell-specific transcripts using mRNA-seq.    Discovered novel ...

Small non-coding RNAs (sncRNAs) are highly abundant RNAs, typically <100 nucleotides long, that act as key regulators of diverse cellular processes. Although thousands of sncRNA genes are known to exist in the human genome, no single database provides searchable, unified ...