USC Team to Use Patch-Clamp, RNA-seq to Study Gene Expression Variability in Single Neurons

by Monica Heger at Genomeweb

Building on a method that combines patch-clamp with single-cell transcriptome sequencing, researchers from the University of Southern California in Los Angeles are applying it to study gene expression variation in neurons.

The team was one of three to recently receive funding from the National Institutes of Health’s Common Fund, through its Single Cell Analysis Program. The other two groups include a team led by the University of San Diego, which is using RNA-seq to create a 3D transcriptional map of the human brain, and a team led by the University of Pennsylvania to use single-cell transcriptome sequencing and functional genomics technology to study transcriptome variability in heart and brain cells.

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