Banded newts have both aquatic and terrestrial forms, going through metamorphosis and various phenotypic changes during their life. In this study, direct RNA sequencing was used to characterize m6A RNA modifications in 12 newts from the Nehalit population. We focused on genes with multiple differentially modified regions in their transcripts.
Highlights:
- Multiple transcripts in banded newts show differential m6A RNA methylation (DMR)
- Tissue-remodeling associated DMR transcripts cluster according to life stage
- Most DMR transcripts do not cluster by life stage, suggesting environmental regulation
- Cross-analysis with differential expression data further indicated that muscle, immune, and connective tissue pathways are co-regulated at both the transcriptional and epitranscriptomic levels.
- These findings provide the first evidence of m6A methylation patterns in O. vittatus and highlight their role in developmental transitions.
Read the paper here: https://www.sciencedirect.com/science/article/pii/S1744117X25003168?via%3Dihub
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Banded newts have both aquatic and terrestrial forms, going through metamorphosis and various phenotypic changes during their life. In this study, direct RNA sequencing was used to characterize m6A RNA modifications in 12 newts from the Nehalit population. We focused on genes with multiple differentially modified regions in their transcripts.
Highlights:
- Multiple transcripts in banded newts show differential m6A RNA methylation (DMR)
- Tissue-remodeling associated DMR transcripts cluster according to life stage
- Most DMR transcripts do not cluster by life stage, suggesting environmental regulation
- Cross-analysis with differential expression data further indicated that muscle, immune, and connective tissue pathways are co-regulated at both the transcriptional and epitranscriptomic levels.
- These findings provide the first evidence of m6A methylation patterns in O. vittatus and highlight their role in developmental transitions.
Read the paper here: https://www.sciencedirect.com/science/article/pii/S1744117X25003168?via%3Dihub
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