An Intuitive Online Platform For Easy Single Cell RNA-Seq Data Visualization And Data Mining Analysis: Dr. Tom

The ever expanding development of basic medical research is creating a huge need for the specialized analysis of unique biological phenomena that cannot be studied with conventional bulk RNA/DNA sequencing methods. The emergence of single-cell sequencing technology has enabled far greater discovery power to the research of such samples but many challenges remain in terms of the quantity of data being generated and the time such analysis entails.

BGI’s Dr. Tom is a web-based solution for the convenient analysis, visualization and interpretation of single cell level RNA data. Using Dr. Tom requires no manual coding experience and the system frees researchers from being reliant on high powered computing infrastructure for their data interrogation needs.

Based on the accumulated experience of thousands of single cell RNA-seq analysis projects, BGI has built the Dr. Tom platform with a wide variety of useful analysis tools for cell clustering, cell annotation and differential analysis to help users optimize the time and quality of their single cell research.

  1. Customized Cell Clustering Analysis

Dr. Tom supports convenient customized cell clustering analysis by allowing users to select target cells on a graphic display. A range of clustering methods are provided to select from. Marker gene calculation methods, cell annotation databases and other parameters can also be adjusted to re-cluster for cell sub-set determination.

BGI

BGI

BGI

  1. Comprehensive Cell Type Annotation

The Dr. Tom platform supports SCSA, SingleR and SciBet software to offer comprehensive cell type annotation options. Further, users can upload their own customized marker database for cell type determination of species without having to rely on public databases.

BGI

  1. Convenient Cell-Gene Dimension Analysis

One-click functionality allows users to transfer between cell dimension and gene dimension data. Gene dimension data can be mined at great depth using analysis tools as common bulk RNA-seq projects.

BGI

BGI

BGI

  1. Advanced DEG Analysis Options

DEG analysis can be carried out via different dimension of clusters, samples, or customized cell sets. Sample/cluster grouping is highly customizable and flexible when using the DEG analysis tools on Dr. Tom.

The Dr. Tom platform complements its powerful analysis tools with the generation of high quality, publication ready figures and charts covering cell clustering, gene statistics, enrichment analysis, pseudotime, RNA velocity and cell communication information. All the figures generated by the Dr. Tom platform can be edited online and downloaded.

BGI

The Dr. Tom platform has already been recognized by thousands of researchers across the world. Besides single cell data visualization and mining ability, the Dr. Tom platform can also be used to analyze other types of RNA, epigenetic and proteome data. To learn more about Dr. Tom system or to get a FREE trial account, please visit https://biosys.bgi.com/ or contact [email protected].

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