An overview of single-cell RNA sequencing and spatial transcriptomics

From Frontline Genomics by Liam Little

Single-cell RNA sequencing (scRNA-seq) has become the most established and widely used technique within single-cell analysis. Spatial transcriptomics is quickly following in the footsteps of scRNA-seq, with spatially resolved transcriptomics named Method of the Year by Nature in 2020.

Single-cell transcriptomics, or scRNA-seq, is widely used for analysing the transcriptome of single-cell populations. With scRNA-seq, gene expression profiling can explore genotype-phenotype relationships at the fine-grained single-cell level.

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