Analysis Suggests Standardization, Randomization Curbs Most Bias in Distributed RNA Sequencing Studies

from GenomeWeb by Andrea Anderson

Through a systematic analysis of messenger RNA and small RNA sequence data generated at several centers as part of a larger project, a large European consortium has confirmed the feasibility of distributing such RNA sequencing across multiple labs.

In a study appearing online last week in Nature Biotechnology, members of the group presented findings from an analysis of more than 450 cell lines subjected to mRNA and sRNA sequencing at one or more sequencing centers in Europe, following standardized Illumina sequencing and sample preparation protocols. (read more…)