The success of mRNA vaccines has been realised, in part, by advances in manufacturing that enabled billions of doses to be produced at sufficient quality and safety. However, mRNA vaccines must be rigorously analysed to measure their integrity and detect ...
Read More »Single-cell RNA-sequencing integration analysis revealed immune cell heterogeneity in five human autoimmune diseases
Autoimmune diseases are a group of diseases caused by abnormal immune responses to functional body parts. Single-cell RNA-sequencing (scRNA-seq) technology provides transcriptomic information at...
Read More »Tasmanian tiger RNA is first to be recovered, sequenced from an extinct animal
A new study shows the isolation and sequencing of more than a century-old RNA molecules from a Tasmanian tiger specimen preserved at room...
Read More »mitoSplitter – A mitochondrial variants-based method for efficient demultiplexing of pooled single-cell RNA-seq
Single-cell RNA-seq (scRNA-seq) analysis of multiple samples separately can be costly and lead to batch effects. Exogenous barcodes or genome-wide RNA mutations can be used to demultiplex pooled scRNA...
Read More »“CHOOSE” – CRISPR-human organoids-scRNA-seq
Does the human brain have an Achilles heel that ultimately leads to Autism? With a revolutionizing novel system that combines brain organoid technology and intricate genetics, researchers...
Read More »SAHMI – denoising sparse microbial signals from single-cell sequencing of mammalian host tissues
Existing genomic sequencing data can be used to study host–microbiome ecosystems; however, distinguishing signals that originate from truly present microbes from contaminating species and artifacts...
Read More »Aging is associated with a systemic transcriptome imbalance
In a new study published in Nature Aging, investigators used artificial intelligence to analyze data from a wide variety of tissues, collected from humans, mice, rats and killifish. They discovered...
Read More »A cross-cohort computational framework to trace tumor tissue-of-origin based on RNA sequencing
Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. CUP patients...
Read More »M3-seq – single-cell massively-parallel multiplexed microbial sequencing
Three Princeton laboratories teamed up to develop a method for studying gene expression patterns of individual bacteria in unprecedented detail...
Read More »Fluent BioSciences awarded NIH SBIR grant to revolutionize single cell analysis
Fluent BioSciences, a cutting edge life sciences company leading the charge in revolutionizing single cell analysis through simple, cost-effective, and...
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