A new CU Boulder-led study sheds light on the genetic mechanisms that allowed sunflowers to undergo a relatively rapid evolutionary transition from wild to domesticated in just over 5,000...

New publication: Predicting clinical outcome of neuroblastoma patients using an integrative network-based approach https://biologydirect.biomedcentral.com/articles/10.1186/s13062-018-0214-9#Sec5 Abstract Background One of the main current challenges in computational biology is to make sense of the huge amounts of multidimensional experimental data that are being ...

Lexogen, a transcriptomics and next-generation sequencing company and Bluebee, a global bioinformatics platform, have announced today the implementation of QuantSeq Unique Molecular Identifiers (UMI) data analysis pipeline on the Bluebee genomics analysis platform. This collaboration offers QuantSeq users utilizing UMIs ...

The major algorithms for quantifying transcriptomics data for differential gene expression analysis were designed for analyzing data from human or human-like genomes, specifically those with single...

Study flow for the identification of a nasal brush-based classifier of asthma by machine learning analysis of RNAseq data. One hundred and ninety subjects with mild/moderate asthma and controls...

RNA-Seq is a widely used technology that allows an efficient genome-wide quantification of gene expressions for, for example, differential expression (DE) analysis. After a brief review of the main issues, methods and tools related to the DE analysis of RNA-Seq ...

Gene expression analysis using next-generation sequencing (NGS) has advantages in throughput, sensitivity and accuracy over qPCR and microarray methods. However, current limitations with library preparation strategies and access to data analysis often makes RNA-seq unnecessarily laborious and confusing. This live ...

Kyoto University researchers report a microfluidic system that physically separates nuclear RNA (nucRNA) and cytoplasmic RNA (cytRNA) from a single cell and enables single-cell integrated nucRNA...

Tumours in sea turtles may be able to be treated using cancer treatments available to humans. A study published in the journal Communications...

Droplet based single cell transcriptomics has recently enabled parallel screening of tens of thousands of single cells. Clustering methods that scale for such high dimensional data without compromising accuracy are scarce. We exploit Locality Sensitive Hashing, an approximate nearest neighbour ...