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Introduction
A full-time position is available within the laboratory for Molecular Neurogenetics (www.molecular-neurogenetics.lu.se) led by Johan Jakobsson. The Jakobsson lab is interested in how gene expression is regulated in the brain and how this process influence neurodegenerative diseases, psychiatric disorders and brain tumors. The current focus is to study the role of epigenetic mechanisms and transposable elements. The technical expertise in the lab includes gene editing, human stem cell cultures, epigenomics, transcriptomics and single cell analysis.
Your position
The candidate will perform bioinformatic single cell RNAseq and single cell DNA-methylation analysis from developing human brain as well as post-mortem tissue from patients with neurodegenerative disorders. The projects will be focused around the investigation of the non-coding parts of the genome including transposable elements. Integration of age, genomics, DNA-methylation and transcriptomics data will a key aspect of the project. If interested, the candidate may have the opportunity to be involved in gene editing experiments of human stem cells.
Your profile
You will be part of a friendly but highly innovative environment. We are thus seeking for a candidate with a high and healthy ambition to discover! You possess a PhD degree in bioinformatics, computer science, data analytics or equivalent, and have experience with single cell analysis. You are interested in developing new algorithms and integrate those for the interpretation of complex datasets. The capacity to interpret, connect and visualize complex data is crucial. Background in neuroscience and/or stem cell biology is a plus. Good speaking/writing English level is a requirement.
The institute
You will be part of the Stem Cell Center within Lund University (Sweden). You will benefit of state-of-the-art services/equipment and be most welcome in a young, friendly and dynamic environment. The university, founded in 1666, is repeatedly ranked among the world’s top 100 universities. With a direct connection to Copenhagen International airport (30 min), Lund is an accessible city and a European hub for research.
Application / Contact
Deadline for application: 30th September 2020
Candidates should send a CV, a short summary of research experience, and contact information for referees to: johan.jakobsson@med.lu.se
Supporting publications:
https://www.nature.com/articles/s41467-019-11150-8
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008036
https://www.sciencedirect.com/science/article/pii/S0168952520301025?via%3Dihub
