RNA sequencing benchmarking across 42 laboratories identifies data quality, sequencing depth, and bioinformatics choices that improve alternative splicing and isoform analysis...
RNA sequencing identified the novel tick-borne ALTNV in febrile patients in China, helping distinguish infections that can resemble Dabie bandavirus disease...
Eclipsebio’s eSTRAND RNA QC uses direct RNA sequencing to measure multiple RNA quality attributes, including identity, poly(A) tails...
Cancer develops through a process of evolution. As cells acquire mutations, some clones gain advantages that allow them to grow faster, survive longer, or resist treatment. Over time, these genetically distinct cell populations can make tumors increasingly difficult to eliminate. Researchers at the Icahn School of Medicine at Mount Sinai and Weill Cornell Medicine in New York discuss the use of multimodal single-cell technologies to study, not only which mutations are present in individual cells, but also how those mutations affect cell behavior. Endogenous variations and analytical tools suitable for phylogenetic reconstruction a, Illustration of chromosomal DNA in the ...
Small nucleolar RNAs, or snoRNAs, are short RNA molecules best known for helping modify and process other RNAs inside cells. Researchers have also discovered that snoRNAs can be cut into even smaller fragments called snoRNA-derived RNAs, or sdRNAs. The biological roles of these sdRNAs are still being worked out, especially in blood formation and acute myeloid leukemia, or AML. A recent study by researchers at the University Hospital Heidelberg in Germany examined whether sdRNAs are simply byproducts of snoRNA processing or whether they can act as independent regulators of gene expression. Cell-type-specific expression signatures of snoRNA-derived RNAs (sdRNAs) in ...