In 1918, people started getting sick. Really sick. A new strain of influenza had arrived, and it quickly spread, becoming a global pandemic that killed millions. Researchers have now pieced together the...
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Imperial College London partners with laboratory in DR Congo for rapid polio detection via NGS of viral RNA
Late detection of poliovirus transmission is one of the greatest risks to polio eradication. Imperial developed a method for rapid detection of polio. Imperial's Vaccine Epidemiology Research Group (VERG)...
Read More »Hereditary fusion genes are identified as genetic factors associated with monozygotic twins
Hereditary fusion genes are identified as genetic factors associated with monozygotic twins A fusion gene is a hybrid gene that juxtaposes two previously independent genes. It is a consequence of somatic genomic alterations, including reversion, deletion, and translocation. The first ...
Read More »In-person RNA-Seq Data Analysis Workshop in Leipzig, Germany (October 25-28, 2022)
Advance your research. Understand RNA-Seq analyses challenges and solve them yourself. Where? Leipzig, Germany When? October 25 – 28, 2022 Link? https://www.ecseq.com/workshops/workshop_2022-08-RNA-Seq-data-analysis The purpose of this workshop is to get a deeper understanding in Next-Generation Sequencing (NGS) with a special focus ...
Read More »How machine learning and RNA-seq are helping patients diagnosed with the most common childhood cancer
New software developed by Peter Mac and collaborators is helping patients diagnosed with acute lymphoblastic leukaemia (ALL) to determine what subtype they have. ALL is the most common...
Read More »nf-rnaSeqCount – a Nextflow pipeline for obtaining raw read counts from RNA-seq data
The rate of raw sequence production through Next-Generation Sequencing (NGS) has been growing exponentially due to improved technology and reduced costs. This has enabled researchers to answer many biological questions through "multi-omics"...
Read More »Characterization and sequence mapping of large RNA and mRNA therapeutics using mass spectrometry
Large RNA including mRNA (mRNA) has emerged as an important new class of therapeutics. Recently, this has been demonstrated by two highly efficacious vaccines based on mRNA sequences encoding for a modified version of the SARS-CoV-2 spike protein. There is ...
Read More »FIRM – Flexible integration of single-cell RNA-sequencing data for large-scale multi-tissue cell atlas datasets
Single-cell RNA-sequencing (scRNA-seq) is being used extensively to measure the mRNA expression of individual cells from deconstructed tissues, organs and even entire organisms to generate cell atlas...
Read More »A LAMP sequencing approach for high-throughput co-detection of SARS-CoV-2 and influenza virus in human saliva
The COVID-19 pandemic has created an urgent need for rapid, effective, and low-cost SARS-CoV-2 diagnostic testing. Researchers at the University of Pennsylvania Perelman School of Medicine describe...
Read More »The modulatory role of ions in stem cell transcriptome dynamics by regulating lineage-specific gene expression patterns
Every species, from bacteria to humans, is capable of regeneration. Regeneration is mediated by the molecular processes that regulate gene expression to control tissue renewal, restoration and growth...
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