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Long non-coding RNAs (lncRNAs) are typically expressed at low levels and are inherently highly variable. This is a fundamental challenge for differential expression (DE) analysis. In this study, Ghent...

We are looking to appoint a highly motivated postdoctoral fellow in cancer and developmental transcriptomics and genetics to join Sam Behjati’s group at the Wellcome Sanger Institute...

By offering high sequencing speed and ultra-high-throughput at a low price, Illumina next-generation sequencing platforms have been widely adopted in recent years. However, an experiment with multiplexed library could be at risk of...

Cancer arises when cells lose control. Deciphering the "blueprint" of cancer cells - outlining how cancer cells hijack specific pathways for uncontrolled proliferation - will lead to more efficient ways to fight it. Joint effort of scientists from the Weizmann Institute of Science and clinicians from major hemato-oncology departments in Israel succeeded...

The Institute of Molecular Biology gGmbH (IMB) is a Centre of Excellence for Life Sciences funded by the Boehringer Ingelheim Foundation. IMB is located at the campus of the Johannes Gutenberg University in Mainz, Germany and offers premium scientific core ...

A challenge for single-cell genomic studies in kidney and other solid tissues is generating a high-quality single-cell suspension that contains rare or difficult-to-dissociate cell types and is free of both RNA degradation and artifactual transcriptional stress...

A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Texas Children’s Hospital has developed a powerful new approach to understand the formation of new neurons in the mammalian adult brain. Published in the journal...

Single-cell RNA sequencing is a powerful tool for studying cellular diversity, for example in cancer where varied tumor cell types determine diagnosis, prognosis and response to therapy. Single-cell technologies generate hundreds to thousands...

While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal...

Single-cell RNA sequencing (scRNA-seq) methods generate sparse gene expression profiles for thousands of single cells in a single experiment. The information in these profiles is sufficient to classify...