RNA-Seq Blog Transcriptome Research & Industry News
Tumor heterogeneity—the complex microenvironment of different cell subpopulations within a single tumor—remains a major challenge...
Read More »Navigating the unCHARTed – web tool explores public sequencing data for cancer research
To splice or not to splice…
Researchers at the University of Michigan Medical School, used Bru-seq and BruChase-seq RNA sequencing to investigate the efficiency of splicing across different human cell types. The results were surprising in that the splicing process appears to...
Read More »New method to add “Time” resolution to your single-cell RNA-seq
The understanding of individual cells has enormously improved with the application of single-cell RNA-sequencing approaches, enabling researchers to...
Read More »A call for direct sequencing of full-length RNAs to identify all modifications
For most organisms, DNA sequences are available, but the complete RNA sequences are not. Here, we call for technologies to sequence full-length RNAs...
Read More »Single-cell RNA sequencing reveals cells that could protect from fatal lung disease
A subset of fibroblasts located in small foci of tissue on the edges of extensive scarring produce a protein that protects against cell aging. Single-cell RNA...
Read More »UTHSC Hosting Open Data COVID-19 RNA Sequence Resource
Faculty members from the University of Tennessee Health Science Center have led the development of PubSeq, a global digital data repository of COVID-19 RNA sequences. PubSeq is open to all interested...
Read More »How much do you know about circRNA research? – II
The discovery of the novel protein-encoding function of circRNA and its role in clinical sciences. The circRNA field is relatively new – in the previous blog (https://www.rna-seqblog.com/how-much-do-you-know-about-circrna-research/), we got acquainted with the basic roles of circRNA, particularly with...
Read More »RNA sequencing uncovers what’s stressing bumblebees
What’s stressing out bumblebees? To find out, York University scientists used next-generation sequencing to look deep inside bumblebees for evidence of pesticide exposure, including...
Read More »New research suggests how tumors evolve to become aggressive form of prostate cancer
Single-cell RNA sequencing of prostate cells from mice with alterations in Pten, RB1 and MYCN identified 10 major cell subtypes and enabled researchers to study tumor heterogeneity with unprecedented resolution. Credit: Dr. Nicholas Brady. The genetic changes that underlie an ...
Read More »RNA-Seq shows that SARS-CoV-2 replication targets nasal ciliated cells early in COVID-19 infection
The establishment of nasal mucosal immunity against SARS-CoV-2 through a nasal vaccine could be the most efficient way to combat COVID-19...
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